High impact information on LOC397703

• Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos [1].
• Synthetic mRNAs made from this cDNA are translated efficiently in Xenopus oocytes where the homeobox protein localizes to the oocyte nucleus [2].
• We have determined the DNA sequence of a Xhox-1 cDNA and this allows us to predict the complete sequence of a vertebrate homeobox protein [2].
• Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis [3].
• Under these conditions, expression of the anterior neural-specific homeobox gene engrailed is not detected, while the notochord-specific epitope recognized by the Tor-70 antibody is expressed in the presence of H2DIDS [4].

Biological context of LOC397703

• During vertebrate left-right development the homeobox gene Pitx2 serves as a mediator between transient nodal signaling in the left lateral plate mesoderm (l-LPM) and asymmetric organ morphogenesis [5].

Anatomical context of LOC397703

• This unprecedented restriction to an anteroposterior band of the endoderm suggests that vertebrate homeobox genes might be involved in specifying positional information not only in the neuroectoderm and mesoderm, but also in the endoderm [6].
• We have previously identified a homeobox-containing transcription factor (PV. 1) which is a likely mediator of the ventralizing effects of BMP4 in the mesoderm [7].
• The homeobox gene PV.1 mediates specification of the prospective neural ectoderm in Xenopus embryos [7].
• The transient expression of homeobox genes in early phases of embryonic development could act synergistically with the expression of other myogenic transcriptional factors to specify a fine level of differentiation of the muscle cells along the body axis [8].
• Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis [9].

References