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Gene Review

nrdB  -  ribonucleotide-diphosphate reductase...

Escherichia coli UTI89

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Disease relevance of nrdB

  • Up to now it was assumed that E. coli possesses only one enzyme for the synthesis of deoxyribonucleotides and only conditional lethal (temperature sensitive) mutants were isolated in nrdB [1].
  • The three self-splicing introns in phage T4 (in the td, sunY and nrdB genes) (Fig. 1a) each have the conserved group I catalytic RNA core structure (Fig. 1b), out of which is looped an open reading frame [2].

High impact information on nrdB


Chemical compound and disease context of nrdB


Biological context of nrdB


Anatomical context of nrdB

  • The number of flagella per unit cell length decreased sharply after shifting the culture temperature from 30 degrees to 40 degrees C in the following Ts mutants: ftsC108, ftsD1033, ftsE1181, ftsF1141, ftsG29, ftsZ84, parA110, dnaB42, nrdB, and dnaG [9].

Analytical, diagnostic and therapeutic context of nrdB

  • By Southern blotting the insertion point was determined to be in nrdB, the structural gene for the ribonucleotide reductase subunit B2 [1].


  1. Characterization of an iron sensitive Mud1 mutant in E. coli lacking the ribonucleotide reductase subunit B2. Hantke, K. Arch. Microbiol. (1988) [Pubmed]
  2. Spontaneous shuffling of domains between introns of phage T4. Bryk, M., Belfort, M. Nature (1990) [Pubmed]
  3. Genes within genes: independent expression of phage T4 intron open reading frames and the genes in which they reside. Gott, J.M., Zeeh, A., Bell-Pedersen, D., Ehrenman, K., Belfort, M., Shub, D.A. Genes Dev. (1988) [Pubmed]
  4. Overproduction and purification of the B2 subunit of ribonucleotide reductase from Escherichia coli. Sjöberg, B.M., Hahne, S., Karlsson, M., Jörnvall, H., Göransson, M., Uhlin, B.E. J. Biol. Chem. (1986) [Pubmed]
  5. Characterization of the mRNA coding for ribonucleoside diphosphate reductase in Escherichia coli. Hanke, P.D., Fuchs, J.A. J. Bacteriol. (1983) [Pubmed]
  6. Bacteriophage T4 nrdA and nrdB genes, encoding ribonucleotide reductase, are expressed both separately and coordinately: characterization of the nrdB promoter. Tseng, M.J., He, P., Hilfinger, J.M., Greenberg, G.R. J. Bacteriol. (1990) [Pubmed]
  7. A novel approach for isolation and mapping of intron mutations in a ribonucleotide reductase encoding gene (nrdB) of bacteriophage T4 using the white halo plaque phenotype. Lal, S.K., Hall, D.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. Expression of nrdA and nrdB genes of Escherichia coli is decreased under anaerobiosis. Casado, C., Llagostera, M., Barbé, J. FEMS Microbiol. Lett. (1991) [Pubmed]
  9. A cell division regulatory mechanism controls the flagellar regulon in Escherichia coli. Nishimura, A., Hirota, Y. Mol. Gen. Genet. (1989) [Pubmed]
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