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Gene Review:

igfbp3 - insulin-like growth factor binding protein 3

Danio rerio

Synonyms: IGFBP-3, SO:0000704, zgc:91788

Chen, J.Y. et al., Li, Y. et al.

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High impact information on igfbp3

IGFBP-3 mRNA is also persistently expressed in the developing inner ears [1].
The IGFBP-3 knocked down embryos had delayed pharyngeal skeleton morphogenesis and greatly reduced pharyngeal cartilage differentiation [1].
Knockdown of IGFBP-3 also significantly decreased inner ear size and disrupted hair cell differentiation and semicircular canal formation [1].
IGFBP-3 mRNA expression is first detected in the migrating cranial neural crest cells and subsequently in pharyngeal arches in zebrafish embryos [1].
These findings suggest that IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish [1].

Biological context of igfbp3

Expression of IGFBP-3 mRNA was throughout the entire embryonic development, with the highest level of expression observed at 36 hours after the onset of development [2].
Zebrafish IGFBP-3 cDNA contains an open reading frame of 879 bp, encoding a polypeptide of 293 amino acid residues [2].
The tissue-specific and developmental stage-specific expression of IGFBP-3 and the hormonal regulation of its expression have also been determined by comparative reverse transcription polymerase chain reaction [2].

Other interactions of igfbp3

Elevated levels of expression of IGFBP-3 were observed 24 hours after injection with IGF-I and 48 hours with IGF-II or insulin [2].

Analytical, diagnostic and therapeutic context of igfbp3

We report the molecular cloning of IGFBP-3 cDNA for zebrafish [2].

References

Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation. Li, Y., Xiang, J., Duan, C. J. Biol. Chem. (2005) [Pubmed]
Molecular cloning and tissue-specific, developmental-stage-specific, and hormonal regulation of IGFBP3 gene in zebrafish. Chen, J.Y., Chen, J.C., Huang, W.T., Liu, C.W., Hui, C.F., Chen, T.T., Wu, J.L. Mar. Biotechnol. (2004) [Pubmed]

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