The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PFKFB3  -  6-phosphofructo-2-kinase/fructose-2,6...

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC407183


High impact information on LOC407183


Biological context of LOC407183


Anatomical context of LOC407183


Associations of LOC407183 with chemical compounds


Analytical, diagnostic and therapeutic context of LOC407183

  • Purified bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) showed two bands with subunit M(r) of 58,000 and 54,000 when analysed by SDS/PAGE [8].


  1. Expression of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Escherichia coli. Role of N-2 proline in degradation of the protein. Lange, A.J., Li, L., Vargas, A.M., Pilkis, S.J. J. Biol. Chem. (1993) [Pubmed]
  2. Isolation of a cDNA for chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Li, L., Lange, A.J., Pilkis, S.J. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  3. Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B. Bertrand, L., Alessi, D.R., Deprez, J., Deak, M., Viaene, E., Rider, M.H., Hue, L. J. Biol. Chem. (1999) [Pubmed]
  4. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. Deprez, J., Vertommen, D., Alessi, D.R., Hue, L., Rider, M.H. J. Biol. Chem. (1997) [Pubmed]
  5. Role of fructose 2,6-bisphosphate in the control of heart glycolysis. Depre, C., Rider, M.H., Veitch, K., Hue, L. J. Biol. Chem. (1993) [Pubmed]
  6. Tolbutamide inhibits cAMP-dependent phosphorylation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Aoki, M., Kaku, K., Inoue, H., Matsutani, A., Kaneko, T. Diabetes (1992) [Pubmed]
  7. Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Ventura, F., Ambrosio, S., Bartrons, R., el-Maghrabi, M.R., Lange, A.J., Pilkis, S.J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  8. The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. Rider, M.H., Vandamme, J., Lebeau, E., Vertommen, D., Vidal, H., Rousseau, G.G., Vandekerckhove, J., Hue, L. Biochem. J. (1992) [Pubmed]
  9. Cloning and expression of novel isoforms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from bovine heart. Vidal, H., Crepin, K.M., Rider, M.H., Hue, L., Rousseau, G.G. FEBS Lett. (1993) [Pubmed]
  10. Isolation of bovine liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase cDNA: bovine liver and heart forms of the enzyme are separate gene products. Lange, A.J., el-Maghrabi, M.R., Pilkis, S.J. Arch. Biochem. Biophys. (1991) [Pubmed]
  11. Comparison of purified bovine heart and rat liver 6-phosphofructo-2-kinase. Evidence for distinct isoenzymes. Rider, M.H., Foret, D., Hue, L. Biochem. J. (1985) [Pubmed]
  12. Inactivation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phenylglyoxal. Evidence for essential arginine residues. Rider, M.H., Hue, L. Eur. J. Biochem. (1992) [Pubmed]
WikiGenes - Universities