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Gene Review

hyd  -  hyperplastic discs

Drosophila melanogaster

Synonyms: CG9484, Dmel\CG9484, E3 ubiquitin-protein ligase hyd, HYD, Hyd, ...
 
 
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High impact information on hyd

 

Biological context of hyd

  • Examination of relative levels of HYD protein in mutant animals support the idea that less severe mutations are those that result in disc overgrowth, while more severe mutations result in variable disc growth phenotypes [5].
  • Sequence analysis of HYD reveals strong similarity to a portion of the C-terminus of poly(A) binding protein and to the RAT 100-kDa PROTEIN, whose function is unknown [5].
  • Analysis of expressed sequence tag sequences and immunoblotting showed that Rat100 is actually a 300-kDa protein expressed mainly in the brain and testis and is similar to the human E3 identified by differential display (EDD) protein and the Drosophila hyperplastic discs gene, mutants of which cause a defect in spermatogenesis [6].
  • In two of the hyperplastic mutants (dco and c43), the imaginal discs show a failure of gap-junctional cell communication, suggesting that this form of cell communication may be involved in termination of proliferation [7].
 

Anatomical context of hyd

 

Associations of hyd with chemical compounds

 

Regulatory relationships of hyd

References

  1. Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Saunders, D.N., Hird, S.L., Withington, S.L., Dunwoodie, S.L., Henderson, M.J., Biben, C., Sutherland, R.L., Ormandy, C.J., Watts, C.K. Mol. Cell. Biol. (2004) [Pubmed]
  2. The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Lee, J.D., Amanai, K., Shearn, A., Treisman, J.E. Development (2002) [Pubmed]
  3. EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. Henderson, M.J., Russell, A.J., Hird, S., Muñoz, M., Clancy, J.L., Lehrbach, G.M., Calanni, S.T., Jans, D.A., Sutherland, R.L., Watts, C.K. J. Biol. Chem. (2002) [Pubmed]
  4. EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Clancy, J.L., Henderson, M.J., Russell, A.J., Anderson, D.W., Bova, R.J., Campbell, I.G., Choong, D.Y., Macdonald, G.A., Mann, G.J., Nolan, T., Brady, G., Olopade, O.I., Woollatt, E., Davies, M.J., Segara, D., Hacker, N.F., Henshall, S.M., Sutherland, R.L., Watts, C.K. Oncogene (2003) [Pubmed]
  5. Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Mansfield, E., Hersperger, E., Biggs, J., Shearn, A. Dev. Biol. (1994) [Pubmed]
  6. Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene. Oughtred, R., Bedard, N., Adegoke, O.A., Morales, C.R., Trasler, J., Rajapurohitam, V., Wing, S.S. Endocrinology (2002) [Pubmed]
  7. The genetic control of cell proliferation in Drosophila imaginal discs. Bryant, P.J., Schmidt, O. J. Cell Sci. Suppl. (1990) [Pubmed]
 
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