High impact information on Fdh

• Female mating behavior is controlled by factors located in the ODH-marked and AMY-marked chromosomes, with the other chromosomes exercising a small additive effect [1].
• Similar crosses were set up involving parental flies with normally heterozygous genetic background as a control.--Significant deviations from mendelian expectation were observed in inbred E-5 flies grown on tributyrin, inbred ODH males grown on octanol, and inbred ODH females grown on ethanol [2].
• Crosses were set up within each of these inbred lines such that simple mendelian ratios were expected, and eggs from these crosses were placed on media with additions simple chemicals likely to interact with alleles of the two loci--octanol and ethanol for the ODH locus and tributyrin and triacetin for the E-5 locus [2].
• A number of separate strains of Drosophila pseudoobscura were inbred for 38 generations of brother-sister mating with forced heterozygosity for two alleles of either the octanol dehydrogenase or esterase-5 locus [2].
• In all experiments, the activities of four enzymes (ADH, ODH, GPDH and AOX) were measured in larvae, pupae and adults [3].

Biological context of Fdh

• Cytogenetic localization by variation in electrophoretic allozyme phenotype: Drosophila Odh [4].
• ODH activities differed according to the Odh genotypes, in that the ODHS allozyme had a higher activity than ODHF [5].
• To analyze this evolutionary event, nucleotide sequences of the Odh (Octanol dehydrogenase) gene were obtained for 43 lethal chromosomal lines from colonizing populations of North America and 5 from South America, in addition to 5 chromosomal lines from Europe with different viabilities and 2 from laboratory marker stocks [6].
• Changes in gene frequencies at the octanol dehydrogenase locus of Drosophila melanogaster imposed by environmental ethanol [7].

Associations of Fdh with chemical compounds

• ODH activities did not appreciably respond to different ethanol treatments [5].

Other interactions of Fdh

• Interaction between the Adh and Odh loci in response to ethanol in Drosophila melanogaster [5].
• Second-instar and early and late third-instar larvae were exposed to different concentrations of ethanol (0, 5, and 7.5%) and 3 days later fresh weights and the activities of ADH, ODH, alpha GPDH, and MDH were measured [5].

References