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Gene Review

SFA1  -  bifunctional alcohol dehydrogenase/S...

Saccharomyces cerevisiae S288c

Synonyms: Alcohol dehydrogenase SFA, FALDH, FDH, FLD, GSH-FDH, ...
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Disease relevance of SFA1


High impact information on SFA1


Biological context of SFA1


Associations of SFA1 with chemical compounds


Other interactions of SFA1


Analytical, diagnostic and therapeutic context of SFA1

  • Northern blot analysis of SNQ and SFA revealed poly(A)+ RNA transcripts of 2 kb and 1.7 kb, respectively [10].


  1. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin, M., Blomberg, A. Mol. Microbiol. (2006) [Pubmed]
  2. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., Stamler, J.S. Nature (2001) [Pubmed]
  3. Engineering of coenzyme specificity of formate dehydrogenase from Saccharomyces cerevisiae. Serov, A.E., Popova, A.S., Fedorchuk, V.V., Tishkov, V.I. Biochem. J. (2002) [Pubmed]
  4. Enhanced formaldehyde detoxification by overexpression of glutathione-dependent formaldehyde dehydrogenase from Arabidopsis. Achkor, H., Díaz, M., Fernández, M.R., Biosca, J.A., Parés, X., Martínez, M.C. Plant Physiol. (2003) [Pubmed]
  5. S-nitrosoglutathione reductase activity of human and yeast glutathione-dependent formaldehyde dehydrogenase and its nuclear and cytoplasmic localisation. Fernández, M.R., Biosca, J.A., Parés, X. Cell. Mol. Life Sci. (2003) [Pubmed]
  6. Molecular structure and genetic regulation of SFA, a gene responsible for resistance to formaldehyde in Saccharomyces cerevisiae, and characterization of its protein product. Wehner, E.P., Rao, E., Brendel, M. Mol. Gen. Genet. (1993) [Pubmed]
  7. Expression cassettes for formaldehyde and fluoroacetate resistance, two dominant markers in Saccharomyces cerevisiae. van den Berg, M.A., Steensma, H.Y. Yeast (1997) [Pubmed]
  8. Secondary 15N isotope effects on the reactions catalyzed by alcohol and formate dehydrogenases. Rotberg, N.S., Cleland, W.W. Biochemistry (1991) [Pubmed]
  9. Physiological role of the glutathione-dependent formaldehyde dehydrogenase in the methylotrophic yeast Candida boidinii. Lee, B., Yurimoto, H., Sakai, Y., Kato, N. Microbiology (Reading, Engl.) (2002) [Pubmed]
  10. Molecular characterization of the two genes SNQ and SFA that confer hyperresistance to 4-nitroquinoline-N-oxide and formaldehyde in Saccharomyces cerevisiae. Gömpel-Klein, P., Mack, M., Brendel, M. Curr. Genet. (1989) [Pubmed]
  11. Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae. Grey, M., Schmidt, M., Brendel, M. Curr. Genet. (1996) [Pubmed]
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