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Gene Review

Adh5  -  alcohol dehydrogenase 5 (class III), chi...

Mus musculus

Synonyms: ADH-B2, Adh-2, Adh-5, Adh2, Adh3, ...
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Disease relevance of Adh5


High impact information on Adh5


Chemical compound and disease context of Adh5


Biological context of Adh5


Anatomical context of Adh5

  • ADH-C2 appeared in the mature epididymis whereas ADH-B2 exhibited no major changes in activity in testis and epididymis during development [13].
  • ADH isozymes were differentially distributed in these tissues of C3H/He mice; ADH-B2 was observed in all tissues and testis cellular preparations examined; ADH-C2 was localized predominantly in the epididymis but was also present in the seminal vesicles, coagulating gland, and prostate gland [13].

Associations of Adh5 with chemical compounds

  • We report that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs) [14].
  • Similarly, immunodepletion with anti-FDH antibody does not remove the endogenous methylating activity for hypomethylated proteins present in extracts from adenosine dialdehyde-treated RAT1 cells [8].
  • Normal mice oxidized low doses of [(14)C]sodium formate (ip 5 mg/kg) to (14)CO(2) at approximately twice the rate of homozygous NEUT2 mice, indicating the presence of another formate-oxidizing system in addition to FDH [9].

Other interactions of Adh5

  • Ontogenetic analyses demonstrated that ADH-B2 is present throughout development from late fetal stages in stomach, liver, and kidney; similar results were found for ADH-C2 in developing kidney and stomach extracts, whereas ADH-A2 exhibited high activity in liver extracts after 3 weeks of age in both sexes and in male kidney extracts after 6 weeks [15].
  • Electrophoretic and activity variants of ADH-C2 among inbred strains of mice have been used to localise the gene encoding this enzyme (Adh-3) and a closely linked temporal locus (Adh-3-t) on chromosome 3 of this organism [16].

Analytical, diagnostic and therapeutic context of Adh5

  • Northern blot analysis using gene-specific probes provided evidence that psi Adh-2 does not produce a mRNA in either liver or kidney, whereas Adh-2 does [1].


  1. Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frame. Foglio, M.H., Duester, G. Eur. J. Biochem. (1996) [Pubmed]
  2. Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: a class III alcohol dehydrogenase. Gutheil, W.G., Holmquist, B., Vallee, B.L. Biochemistry (1992) [Pubmed]
  3. A central role for S-nitrosothiols in plant disease resistance. Feechan, A., Kwon, E., Yun, B.W., Wang, Y., Pallas, J.A., Loake, G.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Bhandari, V., Choo-Wing, R., Chapoval, S.P., Lee, C.G., Tang, C., Kim, Y.K., Ma, B., Baluk, P., Lin, M.I., McDonald, D.M., Homer, R.J., Sessa, W.C., Elias, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp. Bang, I.S., Liu, L., Vazquez-Torres, A., Crouch, M.L., Stamler, J.S., Fang, F.C. J. Biol. Chem. (2006) [Pubmed]
  6. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Liu, L., Yan, Y., Zeng, M., Zhang, J., Hanes, M.A., Ahearn, G., McMahon, T.J., Dickfeld, T., Marshall, H.E., Que, L.G., Stamler, J.S. Cell (2004) [Pubmed]
  7. Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3. Molotkov, A., Fan, X., Deltour, L., Foglio, M.H., Martras, S., Farrés, J., Parés, X., Duester, G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. Tang, J., Frankel, A., Cook, R.J., Kim, S., Paik, W.K., Williams, K.R., Clarke, S., Herschman, H.R. J. Biol. Chem. (2000) [Pubmed]
  9. Methanol toxicity and formate oxidation in NEUT2 mice. Cook, R.J., Champion, K.M., Giometti, C.S. Arch. Biochem. Biophys. (2001) [Pubmed]
  10. Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class. Zheng, Y.W., Bey, M., Liu, H., Felder, M.R. J. Biol. Chem. (1993) [Pubmed]
  11. Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. Viljoen, D.L., Carr, L.G., Foroud, T.M., Brooke, L., Ramsay, M., Li, T.K. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  12. Genetic regulation of alcohol dehydrogenase, aldehyde dehydrogenase and aldehyde oxidase isozymes in the mouse. Holmes, R.S. Adv. Exp. Med. Biol. (1980) [Pubmed]
  13. Genetic variation, cellular distribution and ontogeny of sorbitol dehydrogenase and alcohol dehydrogenase isozymes in male reproductive tissues of the mouse. Holmes, R.S., Jones, J.T., Peters, J. J. Exp. Zool. (1978) [Pubmed]
  14. Protection from experimental asthma by an endogenous bronchodilator. Que, L.G., Liu, L., Yan, Y., Whitehead, G.S., Gavett, S.H., Schwartz, D.A., Stamler, J.S. Science (2005) [Pubmed]
  15. Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Holmes, R.S. Biochem. Genet. (1979) [Pubmed]
  16. Genetic regulation and development of alcohol dehydrogenases in the mouse. Holmes, R.S. Australian and New Zealand journal of medicine. (1981) [Pubmed]
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