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MeSH Review

Fetal Viability

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Disease relevance of Fetal Viability


High impact information on Fetal Viability


Biological context of Fetal Viability


Anatomical context of Fetal Viability

  • Measurement of E1C in both urine and feces was most useful for early pregnancy diagnosis, while E3 was of value in confirming pregnancy and assessing fetal viability [14].
  • The viabilities of the type II alveolar epithelial cells isolated by this method range from 85% to 95%, and the ultrastructural features of the sorted cells were unaltered by AO labeling or sorting [15].
  • High hepatocyte viabilities (91.8+/-1.6% p = 0.036) and yields (2.56+/-0.48 x 10(10)) were achieved consistently, and P450IA1 activity was increased after sodium and chloride concentrations and pH in the perfusates were controlled [16].
  • Hybridoma cultures treated with DMSO up to 0.3% (v/v) possessed cell densities and viabilities comparable to untreated control [17].
  • The effects of latent iron deficiency combined with parenteral subchronic or acute cadmium exposure during pregnancy on maternal and fetal tissue distribution of cadmium, iron and zinc, and on fetal viability were evaluated [18].

Associations of Fetal Viability with chemical compounds

  • These data provide evidence that estradiol and cortisol are useful markers of placental and fetal viability in the common marmoset, and their reduced concentration following energy restriction suggests that restriction is not acting as a classical stressor by increasing cortisol and, subsequently, estradiol concentration [19].
  • On the other hand, the viabilities of H. pylori, MKN-28 cells, and MKN-45 cells were not affected by rebamipide [20].
  • Viabilities of cells exposed to H. pylori for 2, 24, and 48 h, assessed by incorporation of neutral red dye, were 60, 27, and 16%, respectively; however, the viabilities of cells exposed to both H. pylori and acetohydroxamic acid were 92, 46, and 20% after 2, 24, and 48 h, respectively, (P less than 0.001) [21].
  • This conclusion was based on the reduced viabilities of cells treated with both an eliciting agent and an activating agent prior to in vitro treatment with anti-asGM1 + C, as well as by reductions in cytolytic activity of pM phi elicited with peptone and activated by MVE-2, following anti-asGM1 treatment in vitro or administration in vivo [22].
  • Selective killing of embryos in the uterine horn of the ovariectomized side did not exert any influence on the fetal viability in the untreated horn ( nonovariectomized side) and the peripheral progesterone level also remained statistically unaffected [23].

Gene context of Fetal Viability

  • This inhibitory effect was not due to a cytotoxic effect of IL-4, since the viabilities of human mononuclear cells were comparable in the presence and absence of IL-4 [24].
  • Macrophage inhibitory cytokine 1 (MIC 1) is thought to have immunomodulatory actions favouring fetal viability [25].
  • Recent studies have disclosed variable effects of IL-10 on viabilities of human B lineage cells [26].
  • In further exploring the functional significance of vault expression, it was found that supplementing DC cultures with polyclonal or mAbs against the major vault protein led to lower viabilities of LPS- or TNF-alpha-matured monocytes-DC [27].
  • The osteopetrotic mouse, which represents a natural "knockout" of the CSF-1 gene, exhibits a low rate of fetal implantation and poor fetal viability [28].

Analytical, diagnostic and therapeutic context of Fetal Viability


  1. Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia. Wakita, H., Tomimoto, H., Akiguchi, I., Ohnishi, K., Nakamura, S., Kimura, J. Neurosci. Lett. (1992) [Pubmed]
  2. Can pregnancy-associated plasma protein A (PAPP-A) predict the outcome of pregnancy in women with threatened abortion and confirmed fetal viability? Ruge, S., Pedersen, J.F., Sørensen, S., Lange, A.P. Acta obstetricia et gynecologica Scandinavica. (1990) [Pubmed]
  3. Relationship between phospholipid compositions and transport activities of amino acids in Escherichia coli membrane vesicles. Ohta, T., Okuda, S., Takahashi, H. Biochim. Biophys. Acta (1977) [Pubmed]
  4. Exchange of terminal portions of X- and Y-chromosomal short arms in human XY females. Levilliers, J., Quack, B., Weissenbach, J., Petit, C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Strahl, C., Blackburn, E.H. Mol. Cell. Biol. (1996) [Pubmed]
  6. Bile acids with differing hydrophilic-hydrophobic properties do not influence cytokine production by human monocytes and murine Kupffer cells. Bergamini, A., Dini, L., Baiocchi, L., Cappannoli, L., Falasca, L., Bolacchi, F., Capozzi, M., Faggioli, E., Nistri, A., Salanitro, A., Ventura, L., Rocchi, G., Angelico, M. Hepatology (1997) [Pubmed]
  7. Isolation and partial characterizations of oval and hyperplastic bile ductular cell-enriched populations from the livers of carcinogen and noncarcinogen-treated rats. Sirica, A.E., Cihla, H.P. Cancer Res. (1984) [Pubmed]
  8. Direct suppression of natural killer activity in human peripheral blood leukocyte cultures by glucocorticoids and its modulation by interferon. Holbrook, N.J., Cox, W.I., Horner, H.C. Cancer Res. (1983) [Pubmed]
  9. Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility. Geber, A., Hitchcock, C.A., Swartz, J.E., Pullen, F.S., Marsden, K.E., Kwon-Chung, K.J., Bennett, J.E. Antimicrob. Agents Chemother. (1995) [Pubmed]
  10. Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis. Sjöblom, C., Roberts, C.T., Wikland, M., Robertson, S.A. Endocrinology (2005) [Pubmed]
  11. Prolonged skin allograft survival after photodynamic therapy associated with modification of donor skin antigenicity. Obochi, M.O., Ratkay, L.G., Levy, J.G. Transplantation (1997) [Pubmed]
  12. In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: induction of apoptotic cell death by extracellular pro-oxidant action. Morita, K., Arimochi, H., Ohnishi, Y. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  13. Differential effect of hexoses on hamster embryo development in culture. Ludwig, T.E., Lane, M., Bavister, B.D. Biol. Reprod. (2001) [Pubmed]
  14. Application of urinary and fecal steroid measurements for monitoring ovarian function and pregnancy in the bonobo (Pan paniscus) and evaluation of perineal swelling patterns in relation to endocrine events. Heistermann, M., Möhle, U., Vervaecke, H., van Elsacker, L., Hodges, J.K. Biol. Reprod. (1996) [Pubmed]
  15. Isolation of viable type II alveolar epithelial cells by flow cytometry. Wilson, J.S., Steinkamp, J.A., Lehnert, B.E. Cytometry. (1986) [Pubmed]
  16. Analysis of multivariables during porcine liver digestion to improve hepatocyte yield and viability for use in bioartificial liver support systems. Wang, L., Sun, J., Wang, C., Woodman, K., Li, L., Wu, L., Harbour, C., Johnston, B., Shi, L., Horvat, M., Koutalistras, N., Luo, X., Watson, J., Sheil, A.G. Cell transplantation. (2000) [Pubmed]
  17. Improvement of monoclonal antibody production in hybridoma cells by dimethyl sulfoxide. Ling, W.L., Deng, L., Lepore, J., Cutler, C., Cannon-Carlson, S., Wang, Y., Voloch, M. Biotechnol. Prog. (2003) [Pubmed]
  18. Low iron diet and parenteral cadmium exposure in pregnant rats: the effects on trace elements and fetal viability. Piasek, M., Blanusa, M., Kostial, K., Laskey, J.W. Biometals (2004) [Pubmed]
  19. Endocrine changes in full-term pregnancies and pregnancy loss due to energy restriction in the common marmoset (Callithrix jacchus). Tardif, S.D., Ziegler, T.E., Power, M., Layne, D.G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  20. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Hayashi, S., Sugiyama, T., Amano, K., Isogai, H., Isogai, E., Aihara, M., Kikuchi, M., Asaka, M., Yokota, K., Oguma, K., Fujii, N., Hirai, Y. Antimicrob. Agents Chemother. (1998) [Pubmed]
  21. Helicobacter pylori urease activity is toxic to human gastric epithelial cells. Smoot, D.T., Mobley, H.L., Chippendale, G.R., Lewison, J.F., Resau, J.H. Infect. Immun. (1990) [Pubmed]
  22. Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages. Wiltrout, R.H., Santoni, A., Peterson, E.S., Knott, D.C., Overton, W.R., Herberman, R.B., Holden, H.T. J. Leukoc. Biol. (1985) [Pubmed]
  23. Luteolytic influence of intrauterine dead embryos in the early pregnant rat. Kabir, S.N., Pal, A.K., Pakrashi, A. Biol. Reprod. (1984) [Pubmed]
  24. Interleukin-4 inhibits secretion of interleukin-1beta in the response of human cells to mycobacterial heat shock proteins. Méndez-Samperio, P., Badillo-Flores, A., Nuñez-Vazquez, A., Hernandez Garay, M. Clin. Diagn. Lab. Immunol. (1997) [Pubmed]
  25. Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage. Tong, S., Marjono, B., Brown, D.A., Mulvey, S., Breit, S.N., Manuelpillai, U., Wallace, E.M. Lancet (2004) [Pubmed]
  26. The role of IL-10 in human B cell activation, proliferation, and differentiation. Itoh, K., Hirohata, S. J. Immunol. (1995) [Pubmed]
  27. Up-regulation of drug resistance-related vaults during dendritic cell development. Schroeijers, A.B., Reurs, A.W., Scheffer, G.L., Stam, A.G., de Jong, M.C., Rustemeyer, T., Wiemer, E.A., de Gruijl, T.D., Scheper, R.J. J. Immunol. (2002) [Pubmed]
  28. A role for cytokines in early pregnancy. Mathialagan, N., Roberts, R.M. Indian J. Physiol. Pharmacol. (1994) [Pubmed]
  29. Critical progesterone requirement for maintenance of pregnancy in ovariectomized rats. Arkaravichien, W., Kendle, K.E. J. Reprod. Fertil. (1990) [Pubmed]
  30. Assessment of steroid disruption using cultures of whole ovary and/or placenta in rat and in human placental tissue. Piasek, M., Laskey, J.W., Kostial, K., Blanusa, M. International archives of occupational and environmental health. (2002) [Pubmed]
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