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Gene Review

lkb1  -  CG9374 gene product from transcript CG9374-RE

Drosophila melanogaster

Synonyms: CG9374, DmLKB1, Dmel\CG9374, LKB1, LKB1/PEUTZ JEGHERS KINASE, ...
 
 
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Disease relevance of lkb1

 

High impact information on lkb1

  • Here we show that the Drosophila par-4 homologue, lkb1, is required for the early A-P polarity of the oocyte, and for the repolarization of the oocyte cytoskeleton that defines the embryonic A-P axis [1].
  • We show that the level of AMPK phosphorylation increases during calcium-induced tight junction assembly and cell polarization and that this increase depends on the kinase activity of LKB1 [3].
  • Collectively, our studies unprecedentedly elucidate JNK as the downstream mediator of the LKB1-dependent apoptosis, and provide a new paradigm for understanding the diverse LKB1 functions in vivo [2].
  • Furthermore, inhibition of LKB1 resulted in epithelial morphogenesis failure, which was associated with a decrease in JNK activity [2].
  • JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila [2].
 

Biological context of lkb1

References

 
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