The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

lbe  -  ladybird early

Drosophila melanogaster

Synonyms: CG6545, Dmel\CG6545, Hox11-D125, Lb, Lbe, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of lbe

  • Specifically, we demonstrate that mutation of the muscle identity gene msh and misexpression of the heart identity gene lb lead to heart hyperplasia with similar cell fate modifications [1].

High impact information on lbe

  • In addition, we show that the Dorsocross genes are required for normal patterning of the dorsolateral ectoderm and, in particular, the repression of wingless and the ladybird homeobox genes within this area of the germ band [2].
  • Here we show that the homeobox genes ladybird early and ladybird late are expressed in only one muscle progenitor and its progeny: the segmental border muscle founder cell and two precursors of adult muscles [3].
  • In embryos lacking ladybird gene function, specification of two ladybird-expressing myoblast lineages is affected [3].
  • The segregation of the ladybird-positive progenitor requires coordinate action of neurogenic genes and an interplay of inductive Hedgehog and Wingless signals from the overlying ectoderm [3].
  • We find that both early Wingless signaling and ladybird-dependent late Wingless signaling are required for proper heart formation [4].

Biological context of lbe

  • The Drosophila PCR products contained both the lbl (1) and a highly related homeobox sequence, which we named lady-bird-early (lbe) [5].
  • Mutation of a Lbe binding site causes dramatic expansion of expression and abolishes the responsiveness to repression by lbe [6].
  • Furthermore, aberrant glial cell positioning and aberrant spacing of axonal fascicles in the nerve roots observed in embryos with altered ladybird function suggest that the ladybird genes might also control directed cell movements and cell-cell interactions within the developing Drosophila ventral nerve cord [7].
  • A key role for ladybird in leg myogenesis is further supported by its capacity to repress vestigial and to down-regulate the vestigial-governed flight muscle developmental programme [8].

Anatomical context of lbe

  • Conversely, overexpression of Hh or increasing Ras signaling eliminates Lbe expression while expanding Eve within the cardiogenic mesoderm [9].
  • Among those cells that express ladybird are NB 5-6-derived glial cells [7].
  • The RNAi-mediated attenuation of ladybird expression alters properties of developing myotubes, impairing their ability to grow and interact with the internal tendons and epithelial attachment sites [8].

Other interactions of lbe

  • Loss of hh function (while maintaining wg activity) results in the absence of the Eve cells, whereas the Lbe cells are expanded within the cardiac mesoderm [9].
  • Overexpressing the repressor form of Cubitus interruptus (Ci), a Hh pathway antagonist, also results in expansion of Lbe at the expense of Eve, as does lowering Ras signaling [9].


  1. Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila. Jagla, T., Bidet, Y., Da Ponte, J.P., Dastugue, B., Jagla, K. Development (2002) [Pubmed]
  2. The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp. Reim, I., Lee, H.H., Frasch, M. Development (2003) [Pubmed]
  3. ladybird determines cell fate decisions during diversification of Drosophila somatic muscles. Jagla, T., Bellard, F., Lutz, Y., Dretzen, G., Bellard, M., Jagla, K. Development (1998) [Pubmed]
  4. ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors. Jagla, K., Frasch, M., Jagla, T., Dretzen, G., Bellard, F., Bellard, M. Development (1997) [Pubmed]
  5. A distinct class of homeodomain proteins is encoded by two sequentially expressed Drosophila genes from the 93D/E cluster. Jagla, K., Stanceva, I., Dretzen, G., Bellard, F., Bellard, M. Nucleic Acids Res. (1994) [Pubmed]
  6. Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Han, Z., Fujioka, M., Su, M., Liu, M., Jaynes, J.B., Bodmer, R. Dev. Biol. (2002) [Pubmed]
  7. The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells. De Graeve, F., Jagla, T., Daponte, J.P., Rickert, C., Dastugue, B., Urban, J., Jagla, K. Dev. Biol. (2004) [Pubmed]
  8. Shaping Leg Muscles in Drosophila: Role of ladybird, a Conserved Regulator of Appendicular Myogenesis. Maqbool, T., Soler, C., Jagla, T., Daczewska, M., Lodha, N., Palliyil, S., Vijayraghavan, K., Jagla, K. PLoS ONE (2006) [Pubmed]
  9. Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Liu, J., Qian, L., Wessells, R.J., Bidet, Y., Jagla, K., Bodmer, R. Dev. Biol. (2006) [Pubmed]
WikiGenes - Universities