Disease relevance of Epithelial Attachment

• As the experimental gingivitis developed, the number of T cells or neutrophils in the different tissue regions did not change significantly although the most intense vascular ICAM-1 and ELAM-1 staining redistributed to the CT adjacent to the junctional epithelium [1].
• In the cyclosporine group, despite the action on T lymphocytes, no bacterial invasion occurred, but a differentiated PMN layer was present between the apical dental plaque and the junctional epithelium [2].

High impact information on Epithelial Attachment

• Non-keratinized tissues including junctional epithelium, embryonic epidermis and diestrus vaginal epithelium showed little or no Fos labelling [3].
• In particular, IL-8 expression was maximal in the junctional epithelium adjacent to the infecting microorganisms; PMN infiltration was more prominent in the same area [4].
• Human junctional epithelium: demonstration of a new marker, its growth in vitro and characterization by lectin reactivity and keratin expression [5].
• High dietary cholesterol further increased the cell-proliferative activity of the junctional epithelium induced by lipopolysaccharide and proteases [6].
• Matrilysin (matrix metalloproteinase-7) expression in human junctional epithelium [7].

Biological context of Epithelial Attachment

• Surprisingly, the pattern of keratin expression of the epithelium of the pocket lining was found to be essentially similar to that of normal junctional epithelium and the anatomical position of the boundaries between each epithelial phenotype were not significantly altered [8].
• Wound healing in the rabbits included repair of the epithelial attachment complex, keratocyte activation, synthesis of type I collagen, partial restoration of stromal keratan sulfate and type VI collagen, and retrocorneal membrane formation [9].

Anatomical context of Epithelial Attachment

• In peri-implant mucosa, the patterns of staining were similar, except that staining for desmoplakins I & II was generally significantly reduced compared with gingiva, and junctional epithelium co-expressed keratins 13 and 19 [10].
• A technique utilizing sodium deoxycholate to remove junctional epithelial cells from the epithelial attachment zone is described [11].
• A pilot sample of six periodontally-involved teeth indicated greater levels of fluorine in exposed cementum (0.9 leads to 2.4%) compared to cementum apical to the zone of epithelial attachment (0.4 leads to 1.1%) [12].
• The localization of the integrin alpha 6 beta 4, a transmembrane adhesion molecule associated with hemidesmosomes, was studied in mouse junctional epithelium (JE) by the use of monoclonal antibodies in indirect immunofluorescence microscopy [13].
• The implant surface apical of the junctional epithelium and coronal of the bone crest appeared to be in direct contact with a connective tissue [14].

Associations of Epithelial Attachment with chemical compounds

• In normal periodontal tissues, a small number of MIP-2- and CINC-2-positive cells were seen in junctional epithelium (JE), especially in its coronal half [15].
• The blastocyst-endometrial luminal epithelial attachment [16].
• Junctional epithelium amounted to an average of 33% of the defect height in heparin-treated teeth in contrast to 5% following saline treatment [17].
• Areas treated with the surgery and citric acid technique attained moderate amounts of fibrous re-attachment while the other treatment modalities were associated with a long junctional epithelium [18].
• The results demonstrated that junctional epithelium around titanium implants yields PA activity in a manner very similar to that of natural teeth [19].

Gene context of Epithelial Attachment

• Intensity of ICAM-1, ELAM-1 and VCAM-1 staining, however, was consistently higher in the region of the infiltrated connective tissue subjacent to the most coronal extension of the junctional epithelium [20].
• Histochemical examination of periodontal junctional epithelium in p21/p27 double knockout mice [21].
• In situ hybridization study of cytokeratin 4, 13, 16 and 19 mRNAs in human developing junctional epithelium [22].
• Syndecan-1 expression during the formation of junctional epithelium [23].
• In the normal periodontal tissue, small numbers of junctional epithelium (JE) cells and numerous osteocytes embedded in alveolar bone constitutively expressed COX-1 [24].

Analytical, diagnostic and therapeutic context of Epithelial Attachment

• Innervation of the junctional epithelium was investigated in rat molars by means of immunohistochemistry for protein gene product 9.5 (PGP 9.5) at light and electron microscopic levels [25].
• Intravenous infusion of capsaicin or SP caused increased permeability in vessels underlying the junctional epithelium, as indicated by Monastral blue labelling [26].

References