Gene Review:
ci - cubitus interruptus
Drosophila melanogaster
Synonyms:
CG2125, CI, CID, Ce, Ci, ...
- Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Akimaru, H., Chen, Y., Dai, P., Hou, D.X., Nonaka, M., Smolik, S.M., Armstrong, S., Goodman, R.H., Ishii, S. Nature (1997)
- Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M., Ishii, S. J. Biol. Chem. (1999)
- Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos. Angelats, C., Gallet, A., Thérond, P., Fasano, L., Kerridge, S. Dev. Biol. (2002)
- Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Price, M.A., Kalderon, D. Cell (2002)
- Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary. Dahmann, C., Basler, K. Cell (2000)
- Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Méthot, N., Basler, K. Cell (1999)
- Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Chen, C.H., von Kessler, D.P., Park, W., Wang, B., Ma, Y., Beachy, P.A. Cell (1999)
- Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo. Chen, Y., Goodman, R.H., Smolik, S.M. Mol. Cell. Biol. (2000)
- Identification of a tetrameric hedgehog signaling complex. Stegman, M.A., Vallance, J.E., Elangovan, G., Sosinski, J., Cheng, Y., Robbins, D.J. J. Biol. Chem. (2000)
- Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. Schweizer, L., Basler, K. Mech. Dev. (1998)
- Engrailed gene dosage determines whether certain recessive cubitus interruptus alleles exhibit dominance of the adult wing phenotype in Drosophila. Locke, J., Hanna, S. Dev. Genet. (1996)
- Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Ruel, L., Rodriguez, R., Gallet, A., Lavenant-Staccini, L., Thérond, P.P. Nat. Cell Biol. (2003)
- Mechanism of hedgehog signaling during Drosophila eye development. Pappu, K.S., Chen, R., Middlebrooks, B.W., Woo, C., Heberlein, U., Mardon, G. Development (2003)
- Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C., Plessis, A. Curr. Biol. (1998)
- The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. Fukumoto, T., Watanabe-Fukunaga, R., Fujisawa, K., Nagata, S., Fukunaga, R. J. Biol. Chem. (2001)
- The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Parisi, M.J., Lin, H. Cell Res. (1998)
- Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Chen, Y., Cardinaux, J.R., Goodman, R.H., Smolik, S.M. Development (1999)
- Splitting the Hedgehog signal: sex and patterning in Drosophila. Horabin, J.I. Development (2005)
- Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., Thérond, P.P. Cell (1997)
- Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. Olde, B., McCombie, W.R. J. Mol. Neurosci. (1997)
- The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Zhou, Q., Apionishev, S., Kalderon, D. Genetics (2006)
- Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila. Kiger, J.A., O'Shea, C. Genetics (2001)
- Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Alves, G., Limbourg-Bouchon, B., Tricoire, H., Brissard-Zahraoui, J., Lamour-Isnard, C., Busson, D. Mech. Dev. (1998)
- Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Wang, G., Amanai, K., Wang, B., Jiang, J. Genes Dev. (2000)
- The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. Von Ohlen, T., Hooper, J.E. Dev. Biol. (1999)
- Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Chen, Y., Gallaher, N., Goodman, R.H., Smolik, S.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Zhang, W., Zhao, Y., Tong, C., Wang, G., Wang, B., Jia, J., Jiang, J. Dev. Cell (2005)
- Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Domínguez, M., Brunner, M., Hafen, E., Basler, K. Science (1996)
- Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Lessing, D., Nusse, R. Development (1998)
- Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dussillol-Godar, F., Brissard-Zahraoui, J., Limbourg-Bouchon, B., Boucher, D., Fouix, S., Lamour-Isnard, C., Plessis, A., Busson, D. Dev. Biol. (2006)
- Compartmental organization of the Drosophila genital imaginal discs. Chen, E.H., Baker, B.S. Development (1997)
- Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation. Chanas, G., Lavrov, S., Iral, F., Cavalli, G., Maschat, F. Dev. Biol. (2004)
- Genetic dissection of the Drosophila Cubitus interruptus signaling complex. Lefers, M.A., Wang, Q.T., Holmgren, R.A. Dev. Biol. (2001)