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Gene Review

CCAP  -  Crustacean cardioactive peptide

Drosophila melanogaster

Synonyms: CG4910, Cardioacceleratory peptide 2a, Cardioactive peptide, Ccap, DmCCAP, ...
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Disease relevance of Ccap

  • The CCAP gene is expressed in every ganglion in each post-embryonic stage, except in the thoracic ganglia of first- and second-instar larvae [1].

High impact information on Ccap


Biological context of Ccap


Anatomical context of Ccap


Associations of Ccap with chemical compounds

  • Cardiac reversal was evoked pharmacologically by sequentially applying CCAP and glutamate to the heart [14].

Other interactions of Ccap


Analytical, diagnostic and therapeutic context of Ccap


  1. Identification, sequence and expression of a crustacean cardioactive peptide (CCAP) gene in the moth Manduca sexta. Loi, P.K., Emmal, S.A., Park, Y., Tublitz, N.J. J. Exp. Biol. (2001) [Pubmed]
  2. Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Luo, C.W., Dewey, E.M., Sudo, S., Ewer, J., Hsu, S.Y., Honegger, H.W., Hsueh, A.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Park, Y., Kim, Y.J., Adams, M.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior. Park, J.H., Schroeder, A.J., Helfrich-Förster, C., Jackson, F.R., Ewer, J. Development (2003) [Pubmed]
  5. Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. Dewey, E.M., McNabb, S.L., Ewer, J., Kuo, G.R., Takanishi, C.L., Truman, J.W., Honegger, H.W. Curr. Biol. (2004) [Pubmed]
  6. Shaw potassium channel genes in Drosophila. Hodge, J.J., Choi, J.C., O'Kane, C.J., Griffith, L.C. J. Neurobiol. (2005) [Pubmed]
  7. The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster. Baker, J.D., McNabb, S.L., Truman, J.W. J. Exp. Biol. (1999) [Pubmed]
  8. Circadian regulation of the lark RNA-binding protein within identifiable neurosecretory cells. Zhang, X., McNeil, G.P., Hilderbrand-Chae, M.J., Franklin, T.M., Schroeder, A.J., Jackson, F.R. J. Neurobiol. (2000) [Pubmed]
  9. Role of the neuropeptide CCAP in Drosophila cardiac function. Dulcis, D., Levine, R.B., Ewer, J. J. Neurobiol. (2005) [Pubmed]
  10. Amino acid sequence of CAP2b, an insect cardioacceleratory peptide from the tobacco hawkmoth Manduca sexta. Huesmann, G.R., Cheung, C.C., Loi, P.K., Lee, T.D., Swiderek, K.M., Tublitz, N.J. FEBS Lett. (1995) [Pubmed]
  11. Regulating the activity of a cardioacceleratory peptide. Nichols, R., Kaminski, S., Walling, E., Zornik, E. Peptides (1999) [Pubmed]
  12. Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. Luan, H., Lemon, W.C., Peabody, N.C., Pohl, J.B., Zelensky, P.K., Wang, D., Nitabach, M.N., Holmes, T.C., White, B.H. J. Neurosci. (2006) [Pubmed]
  13. CAP2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP. Davies, S.A., Huesmann, G.R., Maddrell, S.H., O'Donnell, M.J., Skaer, N.J., Dow, J.A., Tublitz, N.J. Am. J. Physiol. (1995) [Pubmed]
  14. Glutamatergic innervation of the heart initiates retrograde contractions in adult Drosophila melanogaster. Dulcis, D., Levine, R.B. J. Neurosci. (2005) [Pubmed]
  15. Molecular identification of a Drosophila G protein-coupled receptor specific for crustacean cardioactive peptide. Cazzamali, G., Hauser, F., Kobberup, S., Williamson, M., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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