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Gene Review

5-HT7  -  5-hydroxytryptamine (serotonin) receptor 7

Drosophila melanogaster

Synonyms: 5-HT receptor, 5-HT-dro, 5-HT-dro1, 5-HT7Dro, 5-HT[7]Dro, ...
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High impact information on 5-HT7


Biological context of 5-HT7

  • The 5HT-dro receptor or closely related receptors might be responsible for the serotonin-sensitive cyclase that has been suggested to play a role in learning and modulation of circadian rhythm in a number of invertebrate systems [3].
  • RESULTS: We generated or obtained flies with genetically altered expression of each of three Drosophila serotonin receptor subtypes (d5-HT1A, d5-HT1B, and d5-HT2) and assayed them for baseline sleep phenotypes [4].
  • The first 88 amino acids of the 5HT receptor, isolated by a 5HT-affinity column followed by anion exchange chromatography and C3 reverse-phase HPLC exhibited a 43% sequence homology with Lymnaea stagnalis 5HT-receptor [5].
  • An intron-containing gene encoding a novel human serotonin (5-HT) receptor was isolated from human genomic and cDNA libraries with probes directed to transmembrane regions of the adenylate cyclase stimulatory Drosophila serotonin receptor gene, 5-HTdrol [6].
  • The deduced amino acid sequences of these planarian receptors, which are highly homologous to one another, show significant similarity to that of Drosophila 5HTdrol serotonin receptor [7].

Anatomical context of 5-HT7


Other interactions of 5-HT7


Analytical, diagnostic and therapeutic context of 5-HT7


  1. Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation. Colas, J.F., Launay, J.M., Kellermann, O., Rosay, P., Maroteaux, L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Serotonin receptor cDNA cloned from Lymnaea stagnalis. Sugamori, K.S., Sunahara, R.K., Guan, H.C., Bulloch, A.G., Tensen, C.P., Seeman, P., Niznik, H.B., Van Tol, H.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase. Witz, P., Amlaiky, N., Plassat, J.L., Maroteaux, L., Borrelli, E., Hen, R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. A sleep-promoting role for the Drosophila serotonin receptor 1A. Yuan, Q., Joiner, W.J., Sehgal, A. Curr. Biol. (2006) [Pubmed]
  5. Putative leech dopamine1-like receptor molecular characterization: sequence homologies between dopamine and serotonin leech CNS receptors explain pharmacological cross-reactivities. Salzet, B., Stefano, G.B., Verger-Bocquet, M., Salzet, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  6. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. Bard, J.A., Zgombick, J., Adham, N., Vaysse, P., Branchek, T.A., Weinshank, R.L. J. Biol. Chem. (1993) [Pubmed]
  7. Molecular identification of a G protein-coupled receptor family which is expressed in planarians. Saitoh, O., Yuruzume, E., Watanabe, K., Nakata, H. Gene (1997) [Pubmed]
  8. Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. Colas, J.F., Launay, J.M., Vonesch, J.L., Hickel, P., Maroteaux, L. Mech. Dev. (1999) [Pubmed]
  9. Detection of electrophoretic variants of Notch, PS integrin, and DROP-1 proteins in Drosophila following extraction in guanidine hydrochloride. Zackson, S.L., Graner, M.W., Karr, T.L. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  10. Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Plassat, J.L., Amlaiky, N., Hen, R. Mol. Pharmacol. (1993) [Pubmed]
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