The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

trio  -  CG18214 gene product from transcript...

Drosophila melanogaster

Synonyms: 0368/10, 0959/14, 1372/03, 1386/06, BEST:LD36950, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on trio

  • We propose that distinct signals transduced via Trio and Dock act combinatorially to activate Pak in spatially restricted domains within the growth cone, thereby controlling the direction of axon extension [1].
  • The guanine nucleotide exchange factor, Trio, is essential for Rac function in axon growth and guidance, but not for epithelial morphogenesis or myoblast fusion [2].
  • In both Caenorhabditis elegans and Drosophila, UNC-73/Trio functions in axon guidance by signaling through the Rac GTPase to regulate cytoskeletal rearrangements necessary for growth cone migrations [3].
  • The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans [3].
  • Genetic interactions implicate both Enabled and Trio in LAR signal transduction [4].

Biological context of trio


Anatomical context of trio

  • The Trio guanine nucleotide exchange factor functions in neural development in Caenorhabditis elegans and Drosophila and in the development of neural tissues and skeletal muscle in mouse [6].
  • The Lar-interacting domain of Trio is constitutively tyrosine-phosphorylated when expressed in COS-7 cells and was highly phosphorylated when it was co-transfected with FAK [6].
  • Thus, Trio is essential in order for neurites to faithfully extend on the correct pathways [7].

Other interactions of trio

  • Here, we describe the identification and characterization of the Drosophila counterpart of Trio, a guanine nucleotide exchange factor (GEF) that associates with the receptor phosphatase LAR and regulates GTPase activation in vertebrate cells [8].

Analytical, diagnostic and therapeutic context of trio


  1. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Newsome, T.P., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A., Dickson, B.J. Cell (2000) [Pubmed]
  2. Rac function and regulation during Drosophila development. Hakeda-Suzuki, S., Ng, J., Tzu, J., Dietzl, G., Sun, Y., Harms, M., Nardine, T., Luo, L., Dickson, B.J. Nature (2002) [Pubmed]
  3. The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. Steven, R., Zhang, L., Culotti, J., Pawson, T. Genes Dev. (2005) [Pubmed]
  4. Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting. Maurel-Zaffran, C., Suzuki, T., Gahmon, G., Treisman, J.E., Dickson, B.J. Neuron (2001) [Pubmed]
  5. The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Forsthoefel, D.J., Liebl, E.C., Kolodziej, P.A., Seeger, M.A. Development (2005) [Pubmed]
  6. Signaling between focal adhesion kinase and trio. Medley, Q.G., Buchbinder, E.G., Tachibana, K., Ngo, H., Serra-Pagès, C., Streuli, M. J. Biol. Chem. (2003) [Pubmed]
  7. The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension. Awasaki, T., Saito, M., Sone, M., Suzuki, E., Sakai, R., Ito, K., Hama, C. Neuron (2000) [Pubmed]
  8. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Bateman, J., Shu, H., Van Vactor, D. Neuron (2000) [Pubmed]
WikiGenes - Universities