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Trio  -  trio Rho guanine nucleotide exchange factor

Rattus norvegicus

 
 
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High impact information on Trio

  • Together, these data suggest that control of the cortical actin cytoskeleton, long known to modulate hormone exocytosis and subsequent endocytosis, involves Cdk5-mediated activation of Trio [1].
  • These data demonstrate that Trio controls a signaling cascade that activates RhoG, which in turn activates Rac1 and Cdc42Hs [2].
  • We report here the characterization of Rho signaling pathways activated by the N-terminal GEF domain of Trio (TrioD1) [2].
  • Two isoforms, Trio 9S and Trio 9L, are derived through alternative splicing of Trio exon 48 and are abundantly expressed in rat brain [3].
  • Consistent with the in situ hybridization pattern, Western blot analyses show that Trio levels in the hippocampus and cortex are high at P1, decreasing until P30 [4].
 

Biological context of Trio

  • Cdk5 and Trio modulate endocrine cell exocytosis [1].
  • We have previously described multiple isoforms of Kalirin derived through alternative splicing and multiple transcription start sites, but multiple isoforms of Trio containing different functional domains have not been described [3].
  • Using a new antibody directed against the spectrin-like region of rat Trio coupled with reverse transcription PCR and cDNA sequencing, we have identified 4 novel isoforms of Trio expressed in rat cortex and cerebellum [3].
  • The kinetics of in vivo contrast enhancement was investigated in Sprague-Dawley rats on a Siemens Trio 3 T scanner [5].
  • During embryonic development, Trio, the Drosophila orthologue of Kalirin, plays an essential role in axon guidance; localization of Kalirin to the somatodendritic region of adult neurons provides the basis for future studies of regulation and function [6].
 

Anatomical context of Trio

 

Other interactions of Trio

  • In mammals, Kalirin is expressed predominantly in the nervous system, whereas Trio, broadly expressed throughout the body, is expressed at a lower level in the nervous system [8].
  • The large multidomain Kalirin and Trio proteins containing dual Rho GTPase guanine nucleotide exchange factor (GEF) domains have been implicated in the regulation of neuronal fiber extension and pathfinding during development [8].

References

  1. Cdk5 and Trio modulate endocrine cell exocytosis. Xin, X., Ferraro, F., Bäck, N., Eipper, B.A., Mains, R.E. J. Cell. Sci. (2004) [Pubmed]
  2. TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. Blangy, A., Vignal, E., Schmidt, S., Debant, A., Gauthier-Rouvière, C., Fort, P. J. Cell. Sci. (2000) [Pubmed]
  3. Multiple novel isoforms of Trio are expressed in the developing rat brain. McPherson, C.E., Eipper, B.A., Mains, R.E. Gene (2005) [Pubmed]
  4. Expression of Trio, a member of the Dbl family of Rho GEFs in the developing rat brain. Ma, X.M., Huang, J.P., Eipper, B.A., Mains, R.E. J. Comp. Neurol. (2005) [Pubmed]
  5. Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging. Kaneshiro, T.L., Ke, T., Jeong, E.K., Parker, D.L., Lu, Z.R. Pharm. Res. (2006) [Pubmed]
  6. Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat. Ma, X.M., Johnson, R.C., Mains, R.E., Eipper, B.A. J. Comp. Neurol. (2001) [Pubmed]
  7. Different regulation of the Trio Dbl-Homology domains by their associated PH domains. Bellanger, J.M., Estrach, S., Schmidt, S., Briançon-Marjollet, A., Zugasti, O., Fromont, S., Debant, A. Biol. Cell (2003) [Pubmed]
  8. Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms. May, V., Schiller, M.R., Eipper, B.A., Mains, R.E. J. Neurosci. (2002) [Pubmed]
 
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