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Gene Review:

HGF - hepatocyte growth factor (hepapoietin A;...

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Chen, C. et al., Taylor, K.M. et al., Ikai, A. et al., Hayashi, K. et al., Hyatt, M.A. et al.

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High impact information on HGF

Real-time PCR analyses found that EB exposure disrupted normal patterns of growth factor (IGF-I, IGF-II, fibroblast growth factor-7, fibroblast growth factor-10, and hepatocyte growth factor) and receptor mRNA expression in the uterus [1].
In other epithelial-mesenchymal organs, fibroblast growth factor (FGF)-7 and FGF-10, hepatocyte growth factor (HGF), and insulin-like growth factor (IGF)-I and IGF-II play essential roles in ductal branching morphogenesis [2].
Expression of messenger ribonucleic acids for fibroblast growth factors 7 and 10, hepatocyte growth factor, and insulin-like growth factors and their receptors in the neonatal ovine uterus [2].
The HGF mRNA was expressed during both the estrous cycle and early pregnancy [3].
In situ hybridization demonstrated that HGF mRNA was expressed by stromal cells of the endometrium, whereas c-met mRNA was localized exclusively to luminal and glandular epithelial cells [3].

Biological context of HGF

In the ovine uterus, HGF may stimulate epithelial morphogenesis and differentiated function required for establishment and maintenance of pregnancy, conceptus implantation, and placentation [3].

Anatomical context of HGF

Results indicate that HGF is a stromal-derived paracrine growth factor in the ovine uterus and placenta that is potentially involved in endometrial epithelial-stromal interactions and chorioallantoic stromal-trophectodermal interactions [3].
Northern blot analysis of endometrial RNA revealed expression of a 6-kb mRNA for HGF and an 8-kb mRNA for c-met in ovine endometrium [3].
In the early conceptus, HGF mRNA was expressed by chorioallantoic mesenchyme, and c-met was expressed by trophectoderm [3].
CONCLUSIONS: After cavopulmonary anastomosis, pulmonary artery expression of the hepatocyte growth factor receptor c-Met and one of its downstream effectors, Bcl-2, had increased in the intimal layer and decreased in the medial layer [4].
Because the hepatocyte growth factor signaling promotes increased endothelial cell survival, it may have a role in pulmonary artery remodeling following cavopulmonary anastomosis [4].

Other interactions of HGF

The RT-PCR analyses indicated that expression of FGF-10, HGF, IGF-I, and IGF-II mRNAs increased in the neonatal uterus between PND 1 and 56 [2].
The abundance of mRNA for GH, prolactin, and IGF-II receptors, plus hepatocyte growth factor and suppressor of cytokine signaling-3 were all lower in livers of NR offspring [5].

Analytical, diagnostic and therapeutic context of HGF

Pulmonary expression of the hepatocyte growth factor receptor c-Met shifts from medial to intimal layer after cavopulmonary anastomosis [4].

References

Neonatal estrogen exposure disrupts uterine development in the postnatal sheep. Hayashi, K., Carpenter, K.D., Spencer, T.E. Endocrinology (2004) [Pubmed]
Expression of messenger ribonucleic acids for fibroblast growth factors 7 and 10, hepatocyte growth factor, and insulin-like growth factors and their receptors in the neonatal ovine uterus. Taylor, K.M., Chen, C., Gray, C.A., Bazer, F.W., Spencer, T.E. Biol. Reprod. (2001) [Pubmed]
Expression of hepatocyte growth factor and its receptor c-met in the ovine uterus. Chen, C., Spencer, T.E., Bazer, F.W. Biol. Reprod. (2000) [Pubmed]
Pulmonary expression of the hepatocyte growth factor receptor c-Met shifts from medial to intimal layer after cavopulmonary anastomosis. Ikai, A., Riemer, R.K., Ma, X., Reinhartz, O., Hanley, F.L., Reddy, V.M. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep. Hyatt, M.A., Gopalakrishnan, G.S., Bispham, J., Gentili, S., McMillen, I.C., Rhind, S.M., Rae, M.T., Kyle, C.E., Brooks, A.N., Jones, C., Budge, H., Walker, D., Stephenson, T., Symonds, M.E. J. Endocrinol. (2007) [Pubmed]

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