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FSH  -  Plasma FSH concentration

Sus scrofa

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High impact information on FSH

  • Results: VPA, but not LEV, caused a significant increase of LH-stimulated testosterone secretion and decreased FSH-stimulated estradiol secretion [1].
  • VPA decreased conversion of testosterone to estradiol in both basal and FSH-stimulated cultures, while LEV only decreased testosterone to estradiol conversion after FSH stimulation and only at the highest, nontherapeutic drug concentration [1].
  • Addition of the combination of FSH, LH and PRL during the period of oocyte maturation marginally improved male pronuclear formation rates (41.3 vs 55.6%; P=0.06) [2].
  • FSH-stimulated follicular secretions enhance oocyte maturation in pigs [2].
  • Despite the marked cumuli expansion induced by gonadotropins, uridine uptake was not influenced by LH or FSH [3].

Biological context of FSH


Anatomical context of FSH

  • FSH, which binds to specific receptors on granulosa cells in mammals, plays a key role in folliculogenesis [5].
  • The increase of estrogens was not paralleled by a similar increase of FSH and LH but was related to the increase of the total number of Leydig cells [6].
  • Concentrations of estrogens, testosterone, FSH, and LH were measured in blood plasma [6].
  • Immunohistological detection of LH and FSH in the pituitary gland of treated and control boars showed no quantifiable difference in the amount of these two gonadotropins and no lesions were visible in the hypothalamus and the pituitary gland [7].

Associations of FSH with chemical compounds


Analytical, diagnostic and therapeutic context of FSH

  • To study the developmental characteristics of Meishan pigs, the plasma concentrations of LH, FSH, inhibin, testosterone, estradiol-17beta, progesterone and insulin-like growth factor-I (IGF-I) in young Meishan boars were determined using RIA and ELISA [8].


  1. Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells. Taubøll, E., Gregoraszczuk, E.L., Tworzydø, A., Wójtowicz, A.K., Ropstad, E. Epilepsia (2006) [Pubmed]
  2. FSH-stimulated follicular secretions enhance oocyte maturation in pigs. Ding, J., Foxcroft, G.R. Theriogenology (1994) [Pubmed]
  3. Effects of LH and FSH on the maturation of pig oocytes in vitro. Mattioli, M., Bacci, M.L., Galeati, G., Seren, E. Theriogenology (1991) [Pubmed]
  4. Passive immunization of the pig against gonadotropin releasing hormone during the follicular phase of the estrous cycle. Esbenshade, K.L. Theriogenology (1991) [Pubmed]
  5. Identification of differential gene expression in in vitro FSH treated pig granulosa cells using suppression subtractive hybridization. Bonnet, A., Frappart, P.O., Dehais, P., Tosser-Klopp, G., Hatey, F. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  6. Changes of testicular aromatase expression during fetal development in male pigs (sus scrofa). Haeussler, S., Wagner, A., Welter, H., Claus, R. Reproduction (2007) [Pubmed]
  7. Histomorphological and immunohistochemical findings in testes, bulbourethral glands and brain of immunologically castrated male piglets. Hilbe, M., Jaros, P., Ehrensperger, F., Zlinszky, K., Janett, F., H??ssig, M., Thun, R. Schweiz. Arch. Tierheilkd. (2006) [Pubmed]
  8. Age-related Changes of Reproductive Hormones in Young Meishan Boars. Kanematsu, N., Jin, W., Watanabe, G., Taya, K. J. Reprod. Dev. (2006) [Pubmed]
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