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Gene Review

MT-RNR1  -  mitochondrially encoded 12S RNA

Homo sapiens

Synonyms: RNR1, s-rRNA
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Disease relevance of MT-RNR1


High impact information on MT-RNR1

  • The 26.4-Mb disease interval contains the chromosome 13 nucleolus organizer (RNR1), the centromere, and 44 annotated protein-encoding genes [4].
  • One G --> A substitution and one C --> T substitution were seen in the MTRNR1 and MTRNR2 genes, respectively [5].
  • We have considered the variability of substitution rates and the nonindependence of nucleotide substitution across sites in the srRNA gene in testing alternative hypotheses regarding the branching patterns of eukaryote phylogeny [6].
  • The length polymorphism lies between the cytochrome b and 12S rRNA (srRNA) genes [7].
  • Large-scale gene rearrangements in the mitochondrial genomes of two calanoid copepods Eucalanus bungii and Neocalanus cristatus (Crustacea), with notes on new versatile primers for the srRNA and COI genes [8].

Biological context of MT-RNR1


Associations of MT-RNR1 with chemical compounds

  • Truncation of the C-terminal domain and other RNA Pol II mutations conferred sensitivity to the ribonucleotide reductase inhibitor hydroxyurea and induction of RNR1 and RNR2 mRNAs after UV irradiation was attenuated in these mutant cells [13].

Analytical, diagnostic and therapeutic context of MT-RNR1

  • The small subunit ribosomal RNA (srRNA) gene was amplified from Gyrodactylus salaris using the polymerase chain reaction (PCR), cloned, and the complete gene sequence of 1966 bp determined [14].


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  6. Evolutionary relationships of eukaryotic kingdoms. Kumar, S., Rzhetsky, A. J. Mol. Evol. (1996) [Pubmed]
  7. Phylogenetically informative length polymorphism and sequence variability in mitochondrial DNA of Australian songbirds (Pomatostomus). Edwards, S.V., Wilson, A.C. Genetics (1990) [Pubmed]
  8. Large-scale gene rearrangements in the mitochondrial genomes of two calanoid copepods Eucalanus bungii and Neocalanus cristatus (Crustacea), with notes on new versatile primers for the srRNA and COI genes. Machida, R.J., Miya, M.U., Nishida, M., Nishida, S. Gene (2004) [Pubmed]
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  12. Phylogenetic relationships of the apicomplexan protist Sarcocystis as determined by small subunit ribosomal RNA comparison. Johnson, A.M., Illana, S., Hakendorf, P., Baverstock, P.R. J. Parasitol. (1988) [Pubmed]
  13. A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair. Wong, J.M., Ingles, C.J. Mol. Gen. Genet. (2001) [Pubmed]
  14. Discrimination between Gyrodactylus salaris, G. derjavini and G. truttae (Platyhelminthes: Monogenea) using restriction fragment length polymorphisms and an oligonucleotide probe within the small subunit ribosomal RNA gene. Cunningham, C.O., McGillivray, D.M., MacKenzie, K., Melvin, W.T. Parasitology (1995) [Pubmed]
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