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Gene Review:

HNRNPM - heterogeneous nuclear ribonucleoprotein M

Homo sapiens

Synonyms: CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, ...

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High impact information on HNRPM

The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping [1].
Further in situ hybridization assays located the hnRNP-M encoding gene on human chromosome 19 [1].
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins [2].
Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2 [3].
Sequence analysis showed that NAGR1 is a glycine-, tryptophan-, and methionine-rich protein with no cysteine residues or glycosylation site [4].

Biological context of HNRPM

In patients without acute graft rejection (NAGR), a markedly higher proportion of freshly drawn CD3+/CD4+/iCTLA-4+ cells compared with patients with acute graft rejection (AGR) and an up-regulation of the median percentage of CD3+/CD4+/CD40L+ cells after ex vivo stimulation was found [5].

Anatomical context of HNRPM

Northern blot analysis showed that the mRNA encoding NAGR1 was present as a single transcript of 2.1 kb in the thyroid, but not in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas [4].

References

The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. Gattoni, R., Mahé, D., Mähl, P., Fischer, N., Mattei, M.G., Stévenin, J., Fuchs, J.P. Nucleic Acids Res. (1996) [Pubmed]
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Datar, K.V., Dreyfuss, G., Swanson, M.S. Nucleic Acids Res. (1993) [Pubmed]
Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2. Blanck, O., Perrin, C., Mziaut, H., Darbon, H., Mattei, M.G., Miquelis, R. Genomics (1995) [Pubmed]
Molecular cloning, cDNA analysis, and localization of a monomer of the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to chromosome 19p13.3-13.2. Blanck, O., Perrin, C., Mziaut, H., Darbon, H., Mattei, M.G., Miquelis, R. Genomics (1994) [Pubmed]
CD40L, CD28, and CTLA-4 expression on CD4+ T cells in kidney graft recipients: a relationship with post-transplantation clinical course. Kosmaczewska, A., Magott-Procelewska, M., Frydecka, I., Ciszak, L., Bocko, D., Szteblich, A., Kusnierczyk, P., Patrzalek, D., Szyber, P., Klinger, M. Transpl. Immunol. (2006) [Pubmed]

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HNRNPM	Bos taurus
HNRNPM	Macaca mulatta
Hnrnpm	Mus musculus
HNRNPM	Pan troglodytes
Hnrnpm	Rattus norvegicus

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