Disease relevance of NKG7

• Expression of GIG-1 mRNA was elevated by treatment with G-CSF in normal bone marrow mononuclear cells, as well as in some cases of blast cells obtained from patients with acute myelogenous leukemia (AML) and CML [1].
• The granulocyte colony-stimulating factor (G-CSF)-induced gene, GIG-1, was originally cloned from G-CSF-stimulated bone marrow mononuclear cells obtained from a patient with chronic myelogenous leukemia (CML) [1].

Psychiatry related information on NKG7

• Expression of GIG-1 gene in mature neutrophils was tightly regulated and reactivation of GIG-1 gene by G-CSF in mature neutrophils may represent a compensation process for the protein lost through the activation of these cells, thus implying an important role for this protein in host defense mechanisms [1].

High impact information on NKG7

• The deduced amino acid sequence of p15-T1A-1/NKG7/GIG-1 predicts that the protein possesses four transmembrane domains, and immuno-electron microscopy localizes the endogenous protein to the membranes of cytotoxic granules in NK cells [2].
• These results suggested that GIG-1 protein is an integral component that is accumulated during the differentiation of myeloid cells toward the stage of mature neutrophils [1].
• The GIG-1 mRNA was expressed mainly in the myeloid leukemic cell lines [3].
• NKG7 mRNA is expressed in activated T cells and in A-LAK cells isolated from the peripheral blood of normal individuals, and in normal human kidney, liver, lung and pancreas [4].
• Southern hybridization of NKG7 suggests that NKG7 is a single-copy gene localized to chromosome 19 [4].

Biological context of NKG7

• Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells [4].

Anatomical context of NKG7

• Furthermore, NKG7 mRNA is expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B cells, monocytes, and myeloid cells [4].
• NKG7 mRNA is not expressed in normal human brain, heart, or skeletal muscle [4].

Analytical, diagnostic and therapeutic context of NKG7

• Molecular cloning and characterization of G-CSF induced gene cDNA [3].
• Western blot analysis with anti-GIG-1 peptide antiserum showed the molecular mass of GIG-1 product was about 17 kDa [1].

References