The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NKTR  -  natural killer cell triggering receptor

Homo sapiens

Synonyms: NK-TR protein, NK-tumor recognition protein, Natural-killer cells cyclophilin-related protein, p104
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NKTR

  • Using immunoprecipitation and Western blotting, we found that at least three cytoplasmic host cell proteins, designated p80, p104, and p140, become tyrosine phosphorylated within 5-10 min after exposure to HSV-1 or HSV-2 [1].
  • These results strongly suggest that p104 is an adhesion factor in L. monocytogenes and possibly in other Listeria species and is involved in adhesion to intestinal cells [2].

High impact information on NKTR

  • Using short term culture of fresh human or mouse NK cells, antisense NK-TR-treated NK cells demonstrated strong selective reduction of NK cytotoxicity [3].
  • The natural killer tumor recognition (NK-TR) protein has been shown to be a necessary component for the killing of NK-sensitive and virus-infected targets by the rat RNK-16 cell line [3].
  • Expression of the NK-TR gene is required for NK-like activity in human T cells [4].
  • The isomerase activity of the NK-TR cyclophilin homolog has been determined to be relatively insensitive to inhibition by the immunosuppressive drug cyclosporin A, with an IC50 value of 770 nM as compared to 19 nM for human cyclophilin [5].
  • The boundaries of exons 6-8 and the alternate splicing events in this region are identical to those previously described for the human NKTR gene [6].

Biological context of NKTR

  • We report here the discovery of two sites of alternate splicing in the 5' region of the NK-TR mRNA [7].
  • IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism [7].
  • One of these events caused a frameshift in the open reading frame by splicing in a 28 bp exon within the cyclophilin coding region, resulting in the premature termination of the NK-TR protein [7].
  • On the other hand, nuclear localization and DNA binding activity were preserved in the mutated protein. p104 was immunoprecipitable with four separate polyclonal antibodies recognizing different epitopes of the RB polypeptide, suggesting the presence of most exons in their correct reading frame [8].
  • This study investigated the role of a L. monocytogenes cell-surface protein of 104 kDa (p104) in adhesion to human intestinal enterocyte-like Caco-2 cell lines by transposon (Tn916) mutagenesis and a p104-specific monoclonal antibody (MAb-H7) [2].

Anatomical context of NKTR

  • We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells [7].
  • In this study, we used rabbit antibodies directed against synthetic peptides corresponding to amino acids 476-497 of the NK-TR protein, to examine the expression of the NK-TR antigen in freshly purified human lymphocytes [9].

Associations of NKTR with chemical compounds

  • We have constructed a soluble bacterial fusion protein between the cyclophilin-homologous domain of the NK-TR molecule and glutathione S-transferase (GST) to test for the presence of peptidylprolyl cis-trans-isomerase and chaperone activities and for cyclosporin A binding [5].

Analytical, diagnostic and therapeutic context of NKTR


  1. Herpes simplex virus entry is associated with tyrosine phosphorylation of cellular proteins. Qie, L., Marcellino, D., Herold, B.C. Virology (1999) [Pubmed]
  2. Surface protein p104 is involved in adhesion of Listeria monocytogenes to human intestinal cell line, Caco-2. Pandiripally, V.K., Westbrook, D.G., Sunki, G.R., Bhunia, A.K. J. Med. Microbiol. (1999) [Pubmed]
  3. Selective inhibition of human and mouse natural killer tumor recognition using retroviral antisense in primary natural killer cells: involvement with MHC class I killer cell inhibitory receptors. Ortaldo, J.R., Mason, A.T., Mason, L.H., Winkler-Pickett, R.T., Gosselin, P., Anderson, S.K. J. Immunol. (1997) [Pubmed]
  4. Expression of the NK-TR gene is required for NK-like activity in human T cells. Chambers, C.A., Gallinger, S., Anderson, S.K., Giardina, S., Ortaldo, J.R., Hozumi, N., Roder, J. J. Immunol. (1994) [Pubmed]
  5. The N-terminal cyclophilin-homologous domain of a 150-kilodalton tumor recognition molecule exhibits both peptidylprolyl cis-trans-isomerase and chaperone activities. Rinfret, A., Collins, C., Ménard, R., Anderson, S.K. Biochemistry (1994) [Pubmed]
  6. Characterization of the mouse Nktr gene and promoter. Simons-Evelyn, M., Young, H.A., Anderson, S.K. Genomics (1997) [Pubmed]
  7. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. Rinfret, A., Anderson, S.K. Mol. Immunol. (1993) [Pubmed]
  8. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen. Shew, J.Y., Chen, P.L., Bookstein, R., Lee, E.Y., Lee, W.H. Cell Growth Differ. (1990) [Pubmed]
  9. Cellular distribution of a natural killer cell tumour recognition-related surface antigen in purified human lymphocytes. Alkhatib, G., Murata, K., Roder, J.C. Immunology (1997) [Pubmed]
WikiGenes - Universities