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Gene Review

AADAT  -  aminoadipate aminotransferase

Homo sapiens

Synonyms: 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, AadAT, Alpha-aminoadipate aminotransferase, KAT/AadAT, ...
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Disease relevance of AADAT


Psychiatry related information on AADAT

  • Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease [3].

High impact information on AADAT


Biological context of AADAT


Anatomical context of AADAT

  • However, KAT II-positive astrocytes were intimately associated with select neuron populations, supporting a neuromodulatory role of KYNA [5].

Associations of AADAT with chemical compounds


Other interactions of AADAT


Analytical, diagnostic and therapeutic context of AADAT


  1. Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome. Baran, H., Cairns, N., Lubec, B., Lubec, G. Life Sci. (1996) [Pubmed]
  2. Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3. Chon, H., Matsumura, H., Shimizu, S., Maeda, N., Koga, Y., Takano, K., Kanaya, S. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  3. Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Yu, P., Mosbrook, D.M., Tagle, D.A. Mamm. Genome (1999) [Pubmed]
  4. Increased Functional Diversity of Plant K+ Channels by Preferential Heteromerization of the Shaker-like Subunits AKT2 and KAT2. Xicluna, J., Lacombe, B., Dreyer, I., Alcon, C., Jeanguenin, L., Sentenac, H., Thibaud, J.B., Ch??rel, I. J. Biol. Chem. (2007) [Pubmed]
  5. Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Guidetti, P., Hoffman, G.E., Melendez-Ferro, M., Albuquerque, E.X., Schwarcz, R. Glia (2007) [Pubmed]
  6. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu, P., Li, Z., Zhang, L., Tagle, D.A., Cai, T. Gene (2006) [Pubmed]
  7. Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). Goh, D.L., Patel, A., Thomas, G.H., Salomons, G.S., Schor, D.S., Jakobs, C., Geraghty, M.T. Mol. Genet. Metab. (2002) [Pubmed]
  8. Determination of alpha-aminoadipic acid in brain, peripheral tissues, and body fluids using GC/MS with negative chemical ionization. Guidetti, P., Schwarcz, R. Brain Res. Mol. Brain Res. (2003) [Pubmed]
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