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Gene Review

PIGP  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: DCRC, DCRC-S, DSCR5, DSCRC, DSRC, ...
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Disease relevance of PIGP

  • Both DSCR5 and DSCR6 genes are candidates for the pathogenesis of Down syndrome, although the function of these genes remains to be elucidated [1].

High impact information on PIGP

  • Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5) [2].
  • 2. Recently we have determined 33.5 Mb (more than 99%) of DNA sequence of Chr 21 and, from these sequence data, we identified a novel gene, DSCR5 (transcript = 0.8 kb), from DSCR by combination of computational gene prediction and cDNA screening [2].
  • The DSCR5 gene is expressed in various human tissues examined, whereas the DSCR6 gene is expressed only in limited tissues at low level [1].
  • DSCR5 and DSCR6 genes consist of 6 and 5 exons, respectively [1].
  • The reversal potential for the synaptic potentials (PSP) produced in CPB3b by DSRC stimulation is depolarized relative to the normal membrane potential at lower temperature [3].

Biological context of PIGP


Anatomical context of PIGP


Other interactions of PIGP

  • Blood collected in ACD was supplemented with PIGP solution or PIGPA solution [6].
  • To determine the 5'-end of DSCR5, the oligo-capping method was employed [5].


  1. Isolation of two novel genes, DSCR5 and DSCR6, from Down syndrome critical region on human chromosome 21q22.2. Shibuya, K., Kudoh, J., Minoshima, S., Kawasaki, K., Asakawa, S., Shimizu, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5). Choi, D.K., Suzuki, Y., Yoshimura, S., Togashi, T., Hida, M., Taylor, T.D., Wang, Y., Sugano, S., Hattori, M., Sakaki, Y. Mamm. Genome (2001) [Pubmed]
  3. Cellular mechanism for the temperature sensitive spatial orientation in Clione. Panchin, Y.V. Neuroreport (1997) [Pubmed]
  4. Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5). Ferrando-Miguel, R., Cheon, M.S., Lubec, G. Amino Acids (2004) [Pubmed]
  5. A novel gene, DSCR5, from the distal Down syndrome critical region on chromosome 21q22.2. Togashi, T., Choi, D.K., Taylor, T.D., Suzuki, Y., Sugano, S., Hattori, M., Sakaki, Y. DNA Res. (2000) [Pubmed]
  6. Effects of rejuvenation of blood on 2,3-diphosphoglycerate and adenosine triphosphate and mechanical resistance of red blood cells. Hong, T.V., Wuilleret, B. Vox Sang. (1975) [Pubmed]
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