The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

cdc2c  -  CG10498 gene product from transcript...

Drosophila melanogaster

Synonyms: CDC2C, CDC2c, CDK2, CDK2/CDC2c, CG10498, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on cdc2c


Biological context of cdc2c


Anatomical context of cdc2c

  • Here, we suggest a possible mechanism for cyclin E-Cdk2-dependent differentiation: the establishment of cortical polarity by the centrosome [3].

Physical interactions of cdc2c


Other interactions of cdc2c

  • In higher eukaryotes, cyclin E is thought to control the progression from G1 into S phase of the cell cycle by associating as a regulatory subunit with cdk2 [8].
  • These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development [12].
  • In Drosophila, the activity of DmcycE/CDK2 is rate limiting for entry into S phase and we previously found that the Brm complex can suppress a reduced growth phenotype associated with a hypomorphic DmcycE mutant [10].
  • We have done experiments to investigate a potential functional overlap between two kinases (Dmcdc2 and Dmcdc2c) and two cyclins (cyclin A and cyclin B) [9].
  • These results suggest that Drosophila Cdc25 may directly or indirectly increase the kinase activity of Cyclin E-Cdk2 complexes in vivo, thus driving arrested neuroblasts into cell division [13].


  1. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R., Lehner, C.F. Cell (1994) [Pubmed]
  2. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Moberg, K.H., Bell, D.W., Wahrer, D.C., Haber, D.A., Hariharan, I.K. Nature (2001) [Pubmed]
  3. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Cowan, C.R., Hyman, A.A. Nat. Cell Biol. (2006) [Pubmed]
  4. Drosophila cyclin E interacts with components of the Brahma complex. Brumby, A.M., Zraly, C.B., Horsfield, J.A., Secombe, J., Saint, R., Dingwall, A.K., Richardson, H. EMBO J. (2002) [Pubmed]
  5. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Kolonin, M.G., Finley, R.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Sauer, K., Knoblich, J.A., Richardson, H., Lehner, C.F. Genes Dev. (1995) [Pubmed]
  7. Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress. May, N.R., Thomer, M., Murnen, K.F., Calvi, B.R. J. Cell. Sci. (2005) [Pubmed]
  8. A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Lane, M.E., Elend, M., Heidmann, D., Herr, A., Marzodko, S., Herzig, A., Lehner, C.F. Genetics (2000) [Pubmed]
  9. Cyclins and cdc2 kinases in Drosophila: genetic analyses in a higher eukaryote. Lehner, C.F., Ried, G., Stern, B., Knoblich, J.A. Ciba Found. Symp. (1992) [Pubmed]
  10. SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Zraly, C.B., Marenda, D.R., Dingwall, A.K. Genetics (2004) [Pubmed]
  11. Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Meyer, C.A., Kramer, I., Dittrich, R., Marzodko, S., Emmerich, J., Lehner, C.F. Development (2002) [Pubmed]
  12. Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Chen, X., Oh, S.W., Zheng, Z., Chen, H.W., Shin, H.H., Hou, S.X. Dev. Cell (2003) [Pubmed]
  13. Induction of string rescues the neuroblast proliferation defect in trol mutant animals. Park, Y., Ng, C., Datta, S. Genesis (2003) [Pubmed]
WikiGenes - Universities