The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

FXYD3  -  FXYD domain containing ion transport...

Homo sapiens

Synonyms: Chloride conductance inducer protein Mat-8, FXYD domain-containing ion transport regulator 3, MAT-8, MAT8, Mammary tumor 8 kDa protein, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of FXYD3

  • In conclusion, overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy [1].
  • Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells [2].
 

High impact information on FXYD3

  • In this study, we have identified two splice variants of human FXYD3, or Mat-8, in CaCo-2 cells [3].
  • On the other hand, long human FXYD3 decreases the apparent K(+) affinity only at slightly negative and positive membrane potentials and increases the apparent Na(+) affinity of Na,K-ATPase [3].
  • After co-expression in Xenopus oocytes, both human FXYD3 variants associate stably only with Na,K-ATPase isozymes but not with H,K-ATPase or Ca-ATPase [3].
  • In Na,K-ATPase membrane preparations from shark rectal glands, we have previously identified an FXYD domain-containing protein, phospholemman-like protein from shark, PLMS [4].
  • Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na,K-ATPase by protein kinase c via a novel member of the FXYDY family [5].
 

Biological context of FXYD3

 

Anatomical context of FXYD3

  • Short and long human FXYD3 RNAs and proteins are differentially expressed during differentiation of CaCo-2 cells [3].
 

Associations of FXYD3 with chemical compounds

 

Analytical, diagnostic and therapeutic context of FXYD3

  • FXYD3 antisense expressing T3M4 pancreatic cancer cells were generated and compared to control cells using anchorage-dependent and independent growth assays, and xenotransplantation into nude mice [1].
  • Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS [4].
  • Furthermore, quantitative real time RT-PCR on intact RNAs from 11 paired laser microdissected epithelial tissue samples confirmed up-regulated MAT-8 expression in 6 out of 11 prostate tumors [2].

References

  1. FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. Kayed, H., Kleeff, J., Kolb, A., Ketterer, K., Keleg, S., Felix, K., Giese, T., Penzel, R., Zentgraf, H., Büchler, M.W., Korc, M., Friess, H. Int. J. Cancer (2006) [Pubmed]
  2. Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells. Grzmil, M., Voigt, S., Thelen, P., Hemmerlein, B., Helmke, K., Burfeind, P. Int. J. Oncol. (2004) [Pubmed]
  3. Structural and Functional Properties of Two Human FXYD3 (Mat-8) Isoforms. Bibert, S., Roy, S., Schaer, D., Felley-Bosco, E., Geering, K. J. Biol. Chem. (2006) [Pubmed]
  4. Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS. Mahmmoud, Y.A., Cramb, G., Maunsbach, A.B., Cutler, C.P., Meischke, L., Cornelius, F. J. Biol. Chem. (2003) [Pubmed]
  5. Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na,K-ATPase by protein kinase c via a novel member of the FXYDY family. Mahmmoud, Y.A., Vorum, H., Cornelius, F. J. Biol. Chem. (2000) [Pubmed]
 
WikiGenes - Universities