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Gene Review

FAM3B  -  family with sequence similarity 3, member B

Homo sapiens

Synonyms: 2-21, C21orf11, C21orf76, Cytokine-like protein 2-21, D21M16SJHU19e, ...
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Disease relevance of FAM3B

  • Kaposi's sarcoma-associated human herpesvirus (KSHV) encodes a processivity factor (PF-8, ORF59) that forms homodimers and binds to viral DNA polymerase (Pol-8, ORF9) [1].
  • Azotobacter vinelandii genes contained within the major nif-cluster and designated orf6, nifU, nifS, nifV, orf7, orf8, nifW, nifZ, nifM, and orf9 are organized into at least two overlapping transcriptional units [2].
  • Varicella zoster virus tegument components include the regulatory proteins IE4, IE62, IE63 and the ORFI0 protein, a protein kinase (ORF47) and an abundant protein encoded in ORF9 which is the homolog of HSV VP22 [3].

High impact information on FAM3B


Biological context of FAM3B

  • PANDER (pancreatic derived factor, FAM3B) is a novel cytokine, present in insulin secretory granules, that induces apoptosis of alpha and beta cells of mouse, rat, and human islets in a dose- and time-dependent manner, and may be implicated in diabetes [8].
  • Targeted mutations in binding sites reported to affect interaction with IE4 protein and a putative ORF9 protein binding site were not lethal [9].
  • Other genes contained within the nifUSVWZM gene cluster (orf6, orf7, orf8, and orf9) were not required for Mo-dependent diazotrophic growth [2].
  • Therefore, the complete ORF9, ORF10, ORF11 reported here and the other genes previously reported constitute an operon for the biosynthesis of cephabacins in L. lactamgenus [10].

Anatomical context of FAM3B

  • The patients received 2-21 units of freshly collected placental umbilical cord blood without encountering any clinical, immunological or non-immunological reactions [11].
  • As the neck of the latebra approaches the blastoderm, it flares out to become the nucleus of Pander [12].

Associations of FAM3B with chemical compounds

  • Similarly, chromosomal mutants carrying a deletion in either ORF8, ORF9, or one of the previously sequenced ORFs 17 and 18 have been constructed and shown to accumulate 3-alpha-mycarosyl erythronolide B, as expected for eryC mutants [13].


  1. Processivity factor of KSHV contains a nuclear localization signal and binding domains for transporting viral DNA polymerase into the nucleus. Chen, Y., Ciustea, M., Ricciardi, R.P. Virology (2005) [Pubmed]
  2. Biochemical and genetic analysis of the nifUSVWZM cluster from Azotobacter vinelandii. Jacobson, M.R., Cash, V.L., Weiss, M.C., Laird, N.F., Newton, W.E., Dean, D.R. Mol. Gen. Genet. (1989) [Pubmed]
  3. Interactions among structural proteins of varicella zoster virus. Spengler, M., Niesen, N., Grose, C., Ruyechan, W.T., Hay, J. Arch. Virol. Suppl. (2001) [Pubmed]
  4. Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells. Yang, J., Robert, C.E., Burkhardt, B.R., Young, R.A., Wu, J., Gao, Z., Wolf, B.A. Diabetes (2005) [Pubmed]
  5. Pancreatic-derived factor (FAM3B), a novel islet cytokine, induces apoptosis of insulin-secreting beta-cells. Cao, X., Gao, Z., Robert, C.E., Greene, S., Xu, G., Xu, W., Bell, E., Campbell, D., Zhu, Y., Young, R., Trucco, M., Markmann, J.F., Naji, A., Wolf, B.A. Diabetes (2003) [Pubmed]
  6. The Herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter. Wakenshaw, L., Walters, M.S., Whitehouse, A. J. Virol. (2005) [Pubmed]
  7. Array analysis of viral gene transcription during lytic infection of cells in tissue culture with Varicella-Zoster virus. Cohrs, R.J., Hurley, M.P., Gilden, D.H. J. Virol. (2003) [Pubmed]
  8. Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. Yang, J., Gao, Z., Robert, C.E., Burkhardt, B.R., Gaweska, H., Wagner, A., Wu, J., Greene, S.R., Young, R.A., Wolf, B.A. Biochemistry (2005) [Pubmed]
  9. Mutational analysis of open reading frames 62 and 71, encoding the varicella-zoster virus immediate-early transactivating protein, IE62, and effects on replication in vitro and in skin xenografts in the SCID-hu mouse in vivo. Sato, B., Ito, H., Hinchliffe, S., Sommer, M.H., Zerboni, L., Arvin, A.M. J. Virol. (2003) [Pubmed]
  10. Biosynthetic pathway of cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics. Sohn, Y.S., Nam, D.H., Ryu, D.D. Metab. Eng. (2001) [Pubmed]
  11. Placental umbilical cord whole blood transfusion to combat anemia in the background of tuberculosis and emaciation and its potential role as an immuno-adjuvant therapy for the under-resourced people of the world. Bhattacharya, N. Clinical and experimental obstetrics & gynecology. (2006) [Pubmed]
  12. Magnetic resonance imaging study of the structure of the yolk in the developing avian egg. Falen, S.W., Szeverenyi, N.M., Packard, D.S., Ruocco, M.J. J. Morphol. (1991) [Pubmed]
  13. Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea. Salah-Bey, K., Doumith, M., Michel, J.M., Haydock, S., Cortés, J., Leadlay, P.F., Raynal, M.C. Mol. Gen. Genet. (1998) [Pubmed]
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