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Gene Review:

Ccrl2 - chemokine (C-C motif) receptor-like 2

Mus musculus

Synonyms: 1810047I05Rik, Ackr5, C-C chemokine receptor-like 2, CCR11, Ccr11, ...

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Disease relevance of Ccrl2

Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis [1].

High impact information on Ccrl2

We have recently provided evidence for the presence of an alternative CCL2 receptor in glial cells called L-CCR and have investigated the expression of L-CCR mRNA in a murine EAE model [1].
Prominent expression of L-CCR mRNA was detected in astrocytes and microglia already at early time points throughout the brain and spinal cord supporting the hypothesis that L-CCR expression in glial cells is related to CNS inflammation [1].
It is shown that L-CCR mRNA is expressed in infiltrating macrophages during EAE, but not in infiltrating T cells [1].
LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo [2].
In addition, we examined possible glial expression of the orphan CC chemokine receptor L-CCR that has been identified previously in murine macrophages [2].

Biological context of Ccrl2

Both RT-PCR experiments and in situ hybridization (ISH) experiments in whole lung sections revealed a rapid upregulation of L-CCR mRNA expression as early as 1 hr and 3 hr after OVA challenge [3].

Anatomical context of Ccrl2

We report here expression of L-CCR mRNA in murine astrocytes and microglia [2].
We have investigated the orphan mouse chemokine receptor (L-CCR) in HEK 293 cells, a receptor that was originally described in a mouse macrophage cell line [4].
We demonstrated that L-CCR mRNA expression is strongly upregulated in mouse lung after OVA challenge and is localized in macrophages and bronchial epithelium [3].

Associations of Ccrl2 with chemical compounds

Furthermore, L-CCR mRNA expression was strongly induced after application of bacterial lipopolysaccharide (LPS), both in vitro and in vivo [2].

Analytical, diagnostic and therapeutic context of Ccrl2

Northern blot analysis revealed that L-CCR was specifically expressed in differentiated macrophages after LPS stimulation [5].

References

Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis. Brouwer, N., Zuurman, M.W., Wei, T., Ransohoff, R.M., Boddeke, H.W., Biber, K. Glia (2004) [Pubmed]
LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Zuurman, M.W., Heeroma, J., Brouwer, N., Boddeke, H.W., Biber, K. Glia (2003) [Pubmed]
Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation. Oostendorp, J., Hylkema, M.N., Luinge, M., Geerlings, M., Meurs, H., Timens, W., Zaagsma, J., Postma, D.S., Boddeke, H.W., Biber, K. J. Histochem. Cytochem. (2004) [Pubmed]
Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Biber, K., Zuurman, M.W., Homan, H., Boddeke, H.W. J. Leukoc. Biol. (2003) [Pubmed]
A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. Shimada, T., Matsumoto, M., Tatsumi, Y., Kanamaru, A., Akira, S. FEBS Lett. (1998) [Pubmed]

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CCRL2	Bos taurus
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LOC713715	Macaca mulatta
CCRL2	Pan troglodytes
Ccrl2	Rattus norvegicus

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