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Gene Review

CCRL2  -  chemokine (C-C motif) receptor-like 2

Homo sapiens

Synonyms: ACKR5, C-C chemokine receptor-like 2, CCR11, CCR6, CKRX, ...
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Disease relevance of CCRL2

  • Variations in the HCR (Pg8) gene are unlikely to be causal for familial psoriasis [1].

High impact information on CCRL2


Biological context of CCRL2


Anatomical context of CCRL2


Associations of CCRL2 with chemical compounds

  • RESULTS: Twenty-three out of 24 patients (96%) completed induction therapy and achieved haematological CR (HCR) as well as molecular remission (MR); however, 1 patient (5%) died from retinoic acid syndrome [5].

Other interactions of CCRL2

  • We undertook this study to examine CCRL2 expression in RA, cytokine regulation of expression, and the source of a putative ligand in an attempt to determine the role of this receptor during inflammation [2].
  • Chemokine (CC motif) receptor-like 2 (CCRL2) is an orphan receptor with homology to other CC chemokine receptors [2].

Analytical, diagnostic and therapeutic context of CCRL2


  1. Variations in the HCR (Pg8) gene are unlikely to be causal for familial psoriasis. Chia, N.V., Stuart, P., Nair, R.P., Henseler, T., Jenisch, S., Lim, H.W., Christophers, E., Voorhees, J.J., Elder, J.T. J. Invest. Dermatol. (2001) [Pubmed]
  2. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. Galligan, C.L., Matsuyama, W., Matsukawa, A., Mizuta, H., Hodge, D.R., Howard, O.M., Yoshimura, T. Arthritis Rheum. (2004) [Pubmed]
  3. Genetic Protection against Hepatitis B Virus Conferred by CCR5{Delta}32: Evidence that CCR5 Contributes to Viral Persistence. Thio, C.L., Astemborski, J., Bashirova, A., Mosbruger, T., Greer, S., Witt, M.D., Goedert, J.J., Hilgartner, M., Majeske, A., O'brien, S.J., Thomas, D.L., Carrington, M. J. Virol. (2007) [Pubmed]
  4. Cloning and characterization of a novel human chemokine receptor. Fan, P., Kyaw, H., Su, K., Zeng, Z., Augustus, M., Carter, K.C., Li, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Treatment of acute promyelocytic leukaemia using a combination of all-trans retinoic acid and chemotherapy. Koh, L.P., Goh, Y.T., Teoh, G., Tan, P. Ann. Acad. Med. Singap. (2001) [Pubmed]
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