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Gene Review

Cd36  -  CD36 antigen

Mus musculus

Synonyms: FAT, GPIIIB, GPIV, Glycoprotein IIIb, PAS IV, ...
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High impact information on Cd36

  • The N-Ethyl-N-Nitrosourea-induced germline mutation 3d (Unc3b1(3d/3d)) abolished both MHC class I and II responses elicited by this pathway, whereas a null allele of Cd36 selectively abolished class II responses [1].
  • Indeed, subcellular fractionation demonstrated that plasma membrane fatty acid translocase (FAT/CD36) is exclusively located in lipid rafts, whereas intracellular FAT/CD36 cofractionated with DSMs [2].
  • The enhanced FA utilization induced by FoxO1 was mediated by a severalfold increase in plasma membrane level of the fatty acid translocase FAT/CD36 and eliminated by cell treatment with the CD36 inhibitor sulfo-N-succinimidyl-oleate [3].
  • Exogenous expression of a dominant negative version of mouse Rev-erbbeta decreases the expression of many genes involved in fatty acid/lipid absorption (including Cd36, and Fabp-3 and -4) [4].
  • In muscle, the expression of several genes involved in lipid metabolism, including fatty acid translocase, uncoupling protein-3, peroxisome proliferator-activated receptors (alpha, delta), and carnitine palmitoyl transferase-1, was increased in AT2R-deficient mice [5].

Biological context of Cd36


Anatomical context of Cd36


Associations of Cd36 with chemical compounds

  • Fatty acid translocase (FAT)/CD36 is a glycoprotein involved in multiple membrane functions including uptake of long-chain fatty acids and oxidized low density lipoprotein [8].

Regulatory relationships of Cd36


Other interactions of Cd36


  1. Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Janssen, E., Tabeta, K., Barnes, M.J., Rutschmann, S., McBride, S., Bahjat, K.S., Schoenberger, S.P., Theofilopoulos, A.N., Beutler, B., Hoebe, K. Immunity (2006) [Pubmed]
  2. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Pohl, J., Ring, A., Korkmaz, U., Ehehalt, R., Stremmel, W. Mol. Biol. Cell (2005) [Pubmed]
  3. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. Bastie, C.C., Nahlé, Z., McLoughlin, T., Esser, K., Zhang, W., Unterman, T., Abumrad, N.A. J. Biol. Chem. (2005) [Pubmed]
  4. Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. Ramakrishnan, S.N., Lau, P., Burke, L.J., Muscat, G.E. J. Biol. Chem. (2005) [Pubmed]
  5. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Yvan-Charvet, L., Even, P., Bloch-Faure, M., Guerre-Millo, M., Moustaid-Moussa, N., Ferre, P., Quignard-Boulange, A. Diabetes (2005) [Pubmed]
  6. Liver fatty acid-binding protein gene ablation inhibits branched-chain fatty acid metabolism in cultured primary hepatocytes. Atshaves, B.P., McIntosh, A.M., Lyuksyutova, O.I., Zipfel, W., Webb, W.W., Schroeder, F. J. Biol. Chem. (2004) [Pubmed]
  7. CD36/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1. Zhang, X., Fitzsimmons, R.L., Cleland, L.G., Ey, P.L., Zannettino, A.C., Farmer, E.A., Sincock, P., Mayrhofer, G. Lab. Invest. (2003) [Pubmed]
  8. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. Sato, O., Kuriki, C., Fukui, Y., Motojima, K. J. Biol. Chem. (2002) [Pubmed]
  9. Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Guthmann, F., Schachtrup, C., Tölle, A., Wissel, H., Binas, B., Kondo, H., Owada, Y., Spener, F., Rüstow, B. Biochim. Biophys. Acta (2004) [Pubmed]
  10. Expression and regulation of mRNA for putative fatty acid transport related proteins and fatty acyl CoA synthase in murine epidermis and cultured human keratinocytes. Harris, I.R., Farrell, A.M., Memon, R.A., Grunfeld, C., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (1998) [Pubmed]
  11. New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36. Brinkmann, J.F., Abumrad, N.A., Ibrahimi, A., van der Vusse, G.J., Glatz, J.F. Biochem. J. (2002) [Pubmed]
  12. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Memon, R.A., Tecott, L.H., Nonogaki, K., Beigneux, A., Moser, A.H., Grunfeld, C., Feingold, K.R. Endocrinology (2000) [Pubmed]
  13. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Héron-Milhavet, L., Haluzik, M., Yakar, S., Gavrilova, O., Pack, S., Jou, W.C., Ibrahimi, A., Kim, H., Hunt, D., Yau, D., Asghar, Z., Joseph, J., Wheeler, M.B., Abumrad, N.A., LeRoith, D. Endocrinology (2004) [Pubmed]
  14. Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. Bastie, C., Luquet, S., Holst, D., Jehl-Pietri, C., Grimaldi, P.A. J. Biol. Chem. (2000) [Pubmed]
  15. Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Ring, A., Le Lay, S., Pohl, J., Verkade, P., Stremmel, W. Biochim. Biophys. Acta (2006) [Pubmed]
  16. Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II. Cabrero, A., Jové, M., Planavila, A., Merlos, M., Laguna, J.C., Vázquez-Carrera, M. Mol. Pharmacol. (2003) [Pubmed]
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