Disease relevance of Hgfac

• Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo [1].

High impact information on Hgfac

• Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice [2].
• Similar results were also observed in the acetic acid-induced intestinal injury; the survival rate was 36.6% in HGFA-deficient mice and 84.2% in control mice [2].
• In HGFA-deficient mice, the injured mucosa was not sufficiently covered by regenerated epithelium and the activation of HGF was impaired in the injured colon [2].
• CONCLUSIONS: These results indicate that HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth [2].
• Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-associated Kunitz-type serine proteinase inhibitor that was initially identified as a potent inhibitor of hepatocyte growth factor activator [3].

Biological context of Hgfac

• The amino acid sequence of PHBP is homologous to that of hepatocyte growth factor activator [4].

Anatomical context of Hgfac

• Developmental analysis indicated that there was hardly any staining of HGFA until postnatal day 0 and that noticeable staining was initially detected in the pericentral hepatocytes on postnatal day 3 [5].
• These results suggest that HGFA proteins are produced in the hepatocytes surrounding the efferent hepatic veins in the mouse and that development of the unique distributing pattern takes place postnatally [5].
• Immunoelectron microscopy detected ubiquitous distribution of the gold particle reaction product for HGFA in the cytoplasm of these hepatocytes, especially in the rough endoplasmic reticulum [5].
• Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract [6].
• White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues [7].

Analytical, diagnostic and therapeutic context of Hgfac

• The regenerating process of intestinal mucosa damaged by oral administration of dextran sodium sulfate (DSS) or by rectal administration of acetic acid was examined in both HGFA-deficient and control mice [2].

References