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Gene Review:

EPB41L4B - erythrocyte membrane protein band 4.1 like 4B

Homo sapiens

Synonyms: Band 4.1-like protein 4B, CG1, EHM2, FERM-containing protein CG1, Protein EHM2

Wang, J. et al., Sidjabat, H.E. et al., Chauhan, S. et al., Que, E.L. et al.

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Disease relevance of EPB41L4B

RESULTS: Ehm2 expression is upregulated in prostate cancer cell lines and prostate cancer tissues [1].
Increased expression of Ehm2 leads to decreased adhesion to collagen IV, which has been associated with metastasis in cancers [1].
CONCLUSIONS: Ehm2 is overexpressed in prostate cancer and may enhance disease progression and metastasis [1].
CG 1 isolates belonged to E. coli serotypes O162 : H-, OR : H- or Ont : H-, whereas CG 2 isolates belonged to O153 : HR, OR : HR or OR : H34 [2].

High impact information on EPB41L4B

CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif [3].
Increased expression of the metastasis-associated gene Ehm2 in prostate cancer [1].
Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression [1].
The effect of Ehm2 expression on collagen IV adhesion was tested by transient overexpression and RNA interference [1].
Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation [4].

Biological context of EPB41L4B

A total of 16.5 % of the dog rectal swabs and 4.1% of the hospital environmental swabs yielded MDREC, and on the basis of multiplex PCR, PFGE and plasmid profiling, these were confirmed to belong to either CG 1 or CG 2 [2].

Regulatory relationships of EPB41L4B

Expression profiling analysis identified the human FERM domain-encoding gene EHM2 as uniquely induced in HT-AR1 cells as compared to 16 other FERM domain containing genes [4].

Analytical, diagnostic and therapeutic context of EPB41L4B

Analysis of tissue microarrays revealed that increased Ehm2 expression is associated with biochemical recurrence after radical prostatectomy, which is indicative of more aggressive disease [1].
METHODS: Expression of Ehm2 was examined by quantitative RT-PCR and Western blotting in prostate cell lines and by quantitative RT-PCR, in situ hybridization, and immunohistochemistry in prostate tissues [1].

References

Increased expression of the metastasis-associated gene Ehm2 in prostate cancer. Wang, J., Cai, Y., Penland, R., Chauhan, S., Miesfeld, R.L., Ittmann, M. Prostate (2006) [Pubmed]
Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia. Sidjabat, H.E., Townsend, K.M., Lorentzen, M., Gobius, K.S., Fegan, N., Chin, J.J., Bettelheim, K.A., Hanson, N.D., Bensink, J.C., Trott, D.J. J. Med. Microbiol. (2006) [Pubmed]
A smart magnetic resonance contrast agent for selective copper sensing. Que, E.L., Chang, C.J. J. Am. Chem. Soc. (2006) [Pubmed]
Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. Chauhan, S., Pandey, R., Way, J.F., Sroka, T.C., Demetriou, M.C., Kunz, S., Cress, A.E., Mount, D.W., Miesfeld, R.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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