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Gene Review

Atp8b1  -  ATPase, class I, type 8B, member 1

Mus musculus

Synonyms: AI451886, ATPase class I type 8B member 1, FIC1, Ic, P4-ATPase flippase complex alpha subunit ATP8B1, ...
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Disease relevance of Atp8b1


High impact information on Atp8b1

  • In the small intestine, Fic1 was localized to the apical membrane of epithelial cells [2].
  • The distribution of Fic1 in liver plasma membrane fractions from control and taurocholate-treated rats correlated positively with adenosine triphosphate (ATP)-dependent aminophospholipid (phosphatidyl-serine) translocase activity [2].
  • This report describes the localization of Fic1 in rat liver and intestine, as well as biochemical and transfection studies that support its function as an energy-dependent aminophospholipid translocase [2].
  • The 11 sequenced V lambda I proteins used in this study were assigned to sub-subgroups by comparison with the previously published germ-line V lambda Ia, V lambda Ib, and V lambda Ic sequences [3].
  • Through the use of a functionally unbiased signal peptide trap screen, we have discovered an ATP-dependent aminophospholipid transporter that is exclusively expressed in the acrosomal region of spermatozoa; it is about 62% similar to the flippase, FIC1 [4].

Anatomical context of Atp8b1


Associations of Atp8b1 with chemical compounds

  • Transient transfection of CHOK1 cells with FIC1 cDNA resulted in appearance of FIC1 in membrane preparations and energy-dependent PS translocation in cells [2].

Other interactions of Atp8b1

  • ATP8B1 encodes FIC1, which is expressed in several tissues, most prominently in the intestine, pancreas, and stomach and, to a much lesser extent, in the liver [5].

Analytical, diagnostic and therapeutic context of Atp8b1


  1. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Pawlikowska, L., Groen, A., Eppens, E.F., Kunne, C., Ottenhoff, R., Looije, N., Knisely, A.S., Killeen, N.P., Bull, L.N., Elferink, R.P., Freimer, N.B. Hum. Mol. Genet. (2004) [Pubmed]
  2. Familial intrahepatic cholestasis 1: studies of localization and function. Ujhazy, P., Ortiz, D., Misra, S., Li, S., Moseley, J., Jones, H., Arias, I.M. Hepatology (2001) [Pubmed]
  3. Differentiation of human lambda I variable regions with a monoclonal antibody to a defined, germ-line-encoded idiotope correlates with V lambda Ia chemical structure. Suleyman, S., Hosono, O., Sioud, M., Randen, I., Thompson, K.M., Førre, O., Natvig, J.B. J. Immunol. (1993) [Pubmed]
  4. A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization. Wang, L., Beserra, C., Garbers, D.L. Dev. Biol. (2004) [Pubmed]
  5. Fic1 is expressed at apical membranes of different epithelial cells in the digestive tract and is induced in the small intestine during postnatal development of mice. van Mil, S.W., van Oort, M.M., van den Berg, I.E., Berger, R., Houwen, R.H., Klomp, L.W. Pediatr. Res. (2004) [Pubmed]
  6. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. Eppens, E.F., van Mil, S.W., de Vree, J.M., Mok, K.S., Juijn, J.A., Oude Elferink, R.P., Berger, R., Houwen, R.H., Klomp, L.W. J. Hepatol. (2001) [Pubmed]
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