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Gene Review

CDCA8  -  cell division cycle associated 8

Homo sapiens

Synonyms: BOR, BOREALIN, Borealin, Cell division cycle-associated protein 8, Dasra-B, ...
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Disease relevance of CDCA8

  • However, samples from adults with cholestasis were overestimated, particularly by the CAF method, but the BOR and B-C methods would be suitable for "stat" bilirubin analysis in these samples [1].
  • A pedigree of branchio-oto-renal dysplasia (the BOR syndrome) is reported, including the documentation by serial audiometric studies of the onset and rapid progression of hearing loss in the twin sister of an affected child [2].
  • Molecular analyses indicate that Turlock virus (TUR, Turlock serogroup) and Boraceia virus (BOR, Anopheles B serogroup) have virion RNA species and polypeptides comparable in size to those of members of the Bunyavirus genus and unlike those of members of the newly defined Phlebovirus, Nairovirus, or Uukuvirus genera (Bunyaviridae) [3].
  • Genetic aspects of the BOR syndrome--branchial fistulas, ear pits, hearing loss, and renal anomalies [2].
  • We present a sporadic case of BOR dysplasia associated with tetralogy of Fallot in a 30-month-old girl [4].
  • Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells [5].

High impact information on CDCA8

  • Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments [6].
  • Chromosomal passenger proteins including Aurora B, Survivin, and Borealin/Dasra B, also called CDCA8/FLJ10468, are known to play crucial roles during mitosis and cell division [7].
  • Although the inhibition of LTB4 was greater with the ingestion of 1.5 g GLA-enriched BOR/d, it was not significantly different from the ingestion of 0.48 g/d. Taken together, dietary ingestion of GLA-fortified oils does modulate PMN generation of proinflammatory LTB4 [8].
  • Epoxygenase activity accounted for 58% of the total AA metabolism in the BOR-treated kidney microsomes compared with 33% in the SES-treated rats [9].
  • Dietary gamma-linolenic acid (GLA), a omega-6 polyunsaturated fatty acid found in borage oil (BOR), lowers systolic blood pressure in spontaneously hypertensive rats (SHRs) [9].

Associations of CDCA8 with chemical compounds

  • Whether families that show dominant inheritance of pits, clefts, and deafness without renal anomalies represent variants of the BOR syndrome or a separate entity (the BO syndrome), is still not clear [2].

Analytical, diagnostic and therapeutic context of CDCA8

  • Microsomes and RNA were isolated from the renal cortex of male SHRs fed a basal fat-free diet for 5 weeks to which 11% by weight of sesame oil (SES) or BOR was added [9].
  • The two CS strains (GM739 and BOR), which are hypersensitive to both UV- and gamma-irradiation, exhibit no or only little PLD repair after treatment [10].


  1. Three direct spectrophotometric methods for determination of total bilirubin in neonatal and adult serum, adapted to the Technicon RA-1000 analyzer. Harrison, S.P., Barlow, I.M. Clin. Chem. (1989) [Pubmed]
  2. Genetic aspects of the BOR syndrome--branchial fistulas, ear pits, hearing loss, and renal anomalies. Fraser, F.C., Ling, D., Clogg, D., Nogrady, B. Am. J. Med. Genet. (1978) [Pubmed]
  3. Radioimmune assays and molecular studies that place Anopheles B and Turlock serogroup viruses in the Bunyavirus genus (Bunyaviridae). Klimas, R.A., Ushijima, H., Clerx-Van Haaster, C.M., Bishop, D.H. Am. J. Trop. Med. Hyg. (1981) [Pubmed]
  4. Branchio-oto-renal dysplasia associated with tetralogy of Fallot. Daggilas, A., Antoniades, K., Palasis, S., Aidonis, A. Head & neck. (1992) [Pubmed]
  5. Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Hayama, S., Daigo, Y., Yamabuki, T., Hirata, D., Kato, T., Miyamoto, M., Ito, T., Tsuchiya, E., Kondo, S., Nakamura, Y. Cancer Res. (2007) [Pubmed]
  6. Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments. Newkirk, M.M., Mageed, R.A., Jefferis, R., Chen, P.P., Capra, J.D. J. Exp. Med. (1987) [Pubmed]
  7. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Chang, J.L., Chen, T.H., Wang, C.F., Chiang, Y.H., Huang, Y.L., Wong, F.H., Chou, C.K., Chen, C.M. Exp. Cell Res. (2006) [Pubmed]
  8. Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4. Ziboh, V.A., Fletcher, M.P. Am. J. Clin. Nutr. (1992) [Pubmed]
  9. Induction of Renal Cytochrome P450 Arachidonic Acid Epoxygenase Activity by Dietary {gamma}-Linolenic Acid. Yu, Z., Ng, V.Y., Su, P., Engler, M.M., Engler, M.B., Huang, Y., Lin, E., Kroetz, D.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  10. Abnormal sensitivity of some Cockayne's syndrome cell strains to UV- and gamma-rays. Association with a reduced ability to repair potentially lethal damage. Deschavanne, P.J., Chavaudra, N., Fertil, B., Malaise, E.P. Mutat. Res. (1984) [Pubmed]
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