High impact information on MESP1

• After birth, Mesp1 expression was detected only in mature testes, but in a different isoform from that expressed in the embryo [1].
• A novel gene thus isolated is designated as Mesp1 and encodes a possible transcription factor MesP1 containing a basic helix-loop-helix motif [1].
• Moreover, we have found that somitogenesis in the early stages is more susceptible to changes in the Mesp gene dosage, indicating that a threshold level of Mesp activity must be required for the progression of normal somitogenesis [2].
• The molecular electrostatic potential (MESP) surfaces of neutral, protonated, and deprotonated biguanide have been shown to be similar in their most stable arrangements [3].
• Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development [4].

Biological context of MESP1

• This study compares 123 men with maximal exercise systolic pressures (MESP) of < or =140 mm Hg with 518 men whose maximal exercise systolic pressure was > or =140 mm Hg [5].
• The molecular electrostatic potentials (MESP), the cavity depth analysis, and LmSIR2-hSIRT2 models' superposition suggested that the nicotinamide binding catalytic domain has several minor but potentially important structural differences [6].
• The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling [7].

Anatomical context of MESP1

• The cranio-caudal polarity of each segment is already established in the cranial part of the segmental plate and accompanied by the expression of genes like Delta1, Mesp1, Mesp2, Ulicx-1, and EphA4 which are restricted to one half of the prospective somite [8].
• Magnetic stimulation of cervical spinal roots was shown to elicit sensory potentials (MESP) which could easily be recorded at the fingers with ring electrodes [9].
• Thus, a sample of 728 subjects (average age = 4.6 years), 312 Black (135 male and 180 female) and 413 Indian (223 male and 190 female) was screened using referral criteria based on a Middle Ear Screening Protocol (MESP) [10].
• MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling [7].

Associations of MESP1 with chemical compounds

• The deeper oxygen lone pair MESP minima indicate stronger basicity of 1,n-diols and 2,4-pentanediol (2,4-PeD) as compared to that of vicinal diols [11].
• A sensitive, high efficiency high-performance liquid chromatography (HPLC) method is described for the determination in human plasma of antagonist G and its three major metabolites, deamidated-G (M1), G-minus Met11 (M2) and G[Met11(O)] (M3) [12].

Analytical, diagnostic and therapeutic context of MESP1

• The relation of a low MESP to mortality persisted: (1) whether MESP or work capacity increased from the baseline exercise test to the last performed exercise test, and (2) whether it was measured at low (<6 METs) or high (> or =6 METs) levels of work capacity [5].

References