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Gene Review

FGF7  -  fibroblast growth factor 7

Macaca mulatta

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High impact information on KGF


Biological context of KGF

  • However, KGF strongly inhibited apoptosis in the basalis zone, increased glandular sacculation and folding in this zone, and had a marked trophic effect on the spiral arteries [2].
  • In-situ hybridization revealed that during early gestation, KGF mRNA was strongly expressed in placental mesenchymal cells [3].
  • In vivo, KGF and KGFR comprise a mesenchymal-epithelial cell paracrine system that can mediate epithelial cell mitosis [3].

Anatomical context of KGF


Associations of KGF with chemical compounds

  • At the end of the menstrual cycle, P levels fall, and the abundance of endometrial KGF transcripts decreases approximately 9-fold [2].
  • Interestingly, one gene that we studied, keratinocyte growth factor, that was up-regulated by P (peak E levels vs. PcDNA) was more highly expressed in IcDNA [5].

Analytical, diagnostic and therapeutic context of KGF


  1. Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin. Koji, T., Chedid, M., Rubin, J.S., Slayden, O.D., Csaky, K.G., Aaronson, S.A., Brenner, R.M. J. Cell Biol. (1994) [Pubmed]
  2. Effects of keratinocyte growth factor in the endometrium of rhesus macaques during the luteal-follicular transition. Slayden, O.D., Rubin, J.S., Lacey, D.L., Brenner, R.M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  3. Keratinocyte growth factor and its receptor in the rhesus macaque placenta during the course of gestation. Izumi, S., Slayden, O.D., Rubin, J.S., Brenner, R.M. Placenta (1996) [Pubmed]
  4. Keratinocyte growth factor causes proliferation of urothelium in vivo. Yi, E.S., Shabaik, A.S., Lacey, D.L., Bedoya, A.A., Yin, S., Housley, R.M., Danilenko, D.M., Benson, W., Cohen, A.M., Pierce, G.F. J. Urol. (1995) [Pubmed]
  5. Analysis of differential gene regulation in adequate versus inadequate secretory-phase endometrial complementary deoxyribonucleic acid populations from the rhesus monkey. Okulicz, W.C., Ace, C.I., Longcope, C., Tast, J. Endocrinology (1996) [Pubmed]
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