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Gene Review:

FGF7 - fibroblast growth factor 7

Gallus gallus

Yonei-Tamura, S. et al., Shin, M. et al., Katoh, Y. et al., Roberts, R.D. et al.

Roberts, Ellis,

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High impact information on FGF7

FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos [1].
Remarkably, FGF7 and FGF10 applied in the back induced an ectopic AER in the dorsal median ectoderm [1].
Granulosa and theca cells, dissected from the follicles of laying hens, were cultured in vitro and treated with FGF-1, FGF-2, FGF-5, and FGF-7 [2].
Here, comparative genomics analyses and comparative proteomics analyses on FGF7, FGF10, and FGF22 orthologs were performed [3].
FGF7 mRNA was expressed in fetal heart, placenta, lung, kidney, and blood vessels [3].

Anatomical context of FGF7

Our results suggest that FGF7 and FGF10 directly induce the AER in the ectoderm both of the flank and of the dorsal midline and that these two regions have the competence for AER induction [1].
Here we report that FGF7 and FGF10, members of the fibroblast growth factor family, are the best candidates for the direct inducer of the AER [1].
Fgf10 is expressed both in the proventricular and gizzard mesenchyme while Fgf7 is expressed only in gizzard mesenchyme [4].
To provide basic data to analyze function of FGFs in the developing gut, here we cloned Fgf7 and studied expression patterns of Fgf7, Fgf10 and Fgfr1-4 during the development of chicken stomach (glandular stomach; proventriculus and muscular stomach; gizzard) [4].

References

FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos. Yonei-Tamura, S., Endo, T., Yajima, H., Ohuchi, H., Ide, H., Tamura, K. Dev. Biol. (1999) [Pubmed]
Mitogenic effects of fibroblast growth factors on chicken granulosa and theca cells in vitro. Roberts, R.D., Ellis, R.C. Biol. Reprod. (1999) [Pubmed]
Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Shin, M., Watanuki, K., Yasugi, S. Gene Expr. Patterns (2005) [Pubmed]

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FGF7	Bos taurus
FGF7	Canis lupus familiaris
fgf7	Danio rerio
FGF7	Homo sapiens
FGF7	Macaca mulatta
Fgf7	Mus musculus
FGF7	Pan troglodytes
Fgf7	Rattus norvegicus
fgf7	Xenopus (Silurana) tropicalis

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