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Gene Review

Sectm1b  -  secreted and transmembrane 1B

Mus musculus

Synonyms: 1810003C24Rik, K12, Protein K-12, Secreted and transmembrane protein 1b, Sectm1
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Disease relevance of Sectm1b

  • The order of the genes and the direction of transcription was the same as in Escherichia coli K12 [1].

High impact information on Sectm1b

  • Precipitation experiments using K12-Fc on (35)S-radiolabeled NK cells lysates indicated that the K12 cognate was an approximately 40-kDa protein [2].
  • Thus, K12 and CD7 are cognate proteins that are located next to each other on human chromosome 17q25 [2].
  • We observed histone H4 acetylated at K8 or K12 already prior to full decondensation of the sperm nucleus, suggesting that these marks are transmitted by the spermatozoon [3].
  • The tachykinin-like immunoreactivity of the urinary bladder has been measured in various species by means of an antiserum (K12) having negligible cross-reactivity with substance P [4].
  • The purposes of this study are to compare the expression patterns of KSPGs and keratin 12 (K12) respectively by corneal keratocytes and epithelial cells after three different types of injuries; partial and total epithelial debridement and alkali burn [5].

Chemical compound and disease context of Sectm1b


Biological context of Sectm1b


  1. Construction of defined galE mutants of Salmonella for use as vaccines. Hone, D., Morona, R., Attridge, S., Hackett, J. J. Infect. Dis. (1987) [Pubmed]
  2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. Lyman, S.D., Escobar, S., Rousseau, A.M., Armstrong, A., Fanslow, W.C. J. Biol. Chem. (2000) [Pubmed]
  3. Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin. van der Heijden, G.W., Derijck, A.A., Ramos, L., Giele, M., van der Vlag, J., de Boer, P. Dev. Biol. (2006) [Pubmed]
  4. Tachykinin-like immunoreactivity in the mammalian urinary bladder: correlation with the functions of the capsaicin-sensitive sensory nerves. Maggi, C.A., Geppetti, P., Santicioli, P., Frilli, S., Giuliani, S., Furio, M., Theodorsson, E., Fusco, B., Meli, A. Neuroscience (1988) [Pubmed]
  5. Altered KSPG expression by keratocytes following corneal injury. Carlson, E.C., Wang, I.J., Liu, C.Y., Brannan, P., Kao, C.W., Kao, W.W. Mol. Vis. (2003) [Pubmed]
  6. Nitrosamine-induced mutagenesis in Escherichia coli K12 (343/113). 1. Mutagenic properties of certain aliphatic nitrosamines. Rao, T.K., Allen, B.E., Winton, W., Lijinsky, W., Epler, J.L. Mutat. Res. (1981) [Pubmed]
  7. Concurrent transfer and recombination between plasmids encoding for heat-stable enterotoxin and drug resistance in porcine enterotoxigenic Escherichia coli. Franklin, A., Möllby, R. Med. Microbiol. Immunol. (Berl.) (1983) [Pubmed]
  8. Thermosensitive antibiotic resistance plasmids in enterobacteria. Smith, H.W., Parsell, Z., Green, P. J. Gen. Microbiol. (1978) [Pubmed]
  9. Feeding by mucin and intestinal growth of some enteric bacterial pathogens. Kétyi, I. Acta Microbiol. Hung. (1988) [Pubmed]
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