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Gene Review

TRAPPC1  -  trafficking protein particle complex 1

Homo sapiens

Synonyms: BET5, BET5 homolog, MUM-2, MUM2, Multiple myeloma protein 2, ...
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Disease relevance of TRAPPC1


High impact information on TRAPPC1

  • The cell membranes of the terminally differentiated, highly compacted fibroblasts are rich in IMP (1,300/MUM2, P face) [2].
  • The optically interactive volume of the microtubule subunit, calculated from our electron microscope determination of spindle microtubule distribution (106/mum2), 13 protofilaments per microtubules, an 8 nm repeat distance and our best value for f, is compatible with known subunit dimensions as determined by other means [3].
  • Although transposon insertions are known to suppress recombination and alter the ratio of crossovers to apparent gene conversions, the Mutator 1 transposon insertion in the a1-mum2 allele does not alter the sites at which recombination events resolve [4].
  • Gene MUM-2 is homologous to an essential yeast gene, bet5, that was recently shown to be implicated in the vesicular transport of proteins from the endoplasmic reticulum to the Golgi [5].
  • Both iso-complexes, Bet3-Tpc6A and Bet3-Tpc6B, are able to recruit Mum2, a further TRAPP subunit, and we identify the alpha1-alpha2 loop regions as a binding site for Mum2 [6].

Biological context of TRAPPC1

  • Recombinant A1' alleles isolated from a1-mum2/a1::rdt heterozygotes arose via either crossovers (32 CO events) or noncrossovers (8 NCO events) [7].
  • The P-controlled a1 expression in a1-m2 is Spm dependent, and the mutant phenotype of a1-mum2 is suppressed in the pericarp in the absence of the autonomous MuDR element [8].

Anatomical context of TRAPPC1

  • The average mitochondrial fraction of the fiber volume is close to 4 percent and the mean size of a mitochondrion is about 0.1 mum2 [9].
  • Although both membranes appear to possess about 1,700 intramembranous particles per mum2, those of the luminal membrane tend to be significantly larger in size [10].
  • The heterogeneous tissue explant MUM-2 led to the derivation of two clonal cell lines: MUM-2B and MUM-2C [11].
  • The number of nuclear pores/mum2 nuclear membrane was not correlated with biological malignancy [12].

Associations of TRAPPC1 with chemical compounds

  • Here, we investigated the effect of Mutator and Spm insertions on the expression of the flavonoid biosynthetic gene a1, independently regulated by the transcription factors C1 and P. The a1-mum2 and a1-m2 alleles carry Mu1 and Spm insertions, respectively, in a cis-element (ARE) of unknown function located between the P- and C1-binding sites [8].

Analytical, diagnostic and therapeutic context of TRAPPC1

  • The mean cross-sectional area of the muscle fibres in the emphysematous group was 1069-5 mum2 and this was significantly greater than the mean of the control group which was 851-0 mum2 [13].
  • An acoustic standing wave is generated in etched glass channels (600 x 61 mum2) by miniature ultrasonic transducers (550 x 550 x 200 mum3) [14].
  • The diffusion coefficient was found to be 76.9 mum2 x s(-1) by analytical gel filtration [15].


  1. Plasma membrane structures of medulloblastoma and cerebellar sarcoma. Tani, E., Morimura, T., Kaba, K., Higashi, N. Acta Neuropathol. (1975) [Pubmed]
  2. Freeze-fracture studies of the developing cell surface. I. The plasmalemma of the corneal fibroblast. Hasty, D.L., Hay, E.D. J. Cell Biol. (1977) [Pubmed]
  3. Microtubular origin of mitotic spindle form birefringence. Demonstration of the applicability of Wiener's equation. Sato, H., Ellis, G.W., Inoué, S. J. Cell Biol. (1975) [Pubmed]
  4. Meiotic recombination break points resolve at high rates at the 5' end of a maize coding sequence. Xu, X., Hsia, A.P., Zhang, L., Nikolau, B.J., Schnable, P.S. Plant Cell (1995) [Pubmed]
  5. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. Chiari, R., Foury, F., De Plaen, E., Baurain, J.F., Thonnard, J., Coulie, P.G. Cancer Res. (1999) [Pubmed]
  6. Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2. Kümmel, D., Müller, J.J., Roske, Y., Henke, N., Heinemann, U. J. Mol. Biol. (2006) [Pubmed]
  7. MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 gene. Yandeau-Nelson, M.D., Zhou, Q., Yao, H., Xu, X., Nikolau, B.J., Schnable, P.S. Genetics (2005) [Pubmed]
  8. Transposon insertions in the promoter of the Zea mays a1 gene differentially affect transcription by the Myb factors P and C1. Pooma, W., Gersos, C., Grotewold, E. Genetics (2002) [Pubmed]
  9. Human muscle fiber fine structure: morphometric data on controls. Jerusalem, F., Engel, A.G., Peterson, H.A. Neurology (1975) [Pubmed]
  10. Membrane structural specialization of the toad urinary bladder revealed by the freeze-fracture technique. I. The granular cell. Wade, J.B., DiScala, V.A., Karnovsky, M.J. J. Membr. Biol. (1975) [Pubmed]
  11. Molecular determinants of human uveal melanoma invasion and metastasis. Seftor, E.A., Meltzer, P.S., Kirschmann, D.A., Pe'er, J., Maniotis, A.J., Trent, J.M., Folberg, R., Hendrix, M.J. Clin. Exp. Metastasis (2002) [Pubmed]
  12. Freeze-fracture study of human brain tumors. Tani, E., Higashi, N. Child's brain. (1975) [Pubmed]
  13. The cross sectional area of diaphragmatic muscle fibres in emphysema, measured by an automated image analysis system. Scott, K.W., Hoy, J. J. Pathol. (1976) [Pubmed]
  14. Noninvasive acoustic cell trapping in a microfluidic perfusion system for online bioassays. Evander, M., Johansson, L., Lilliehorn, T., Piskur, J., Lindvall, M., Johansson, S., Almqvist, M., Laurell, T., Nilsson, J. Anal. Chem. (2007) [Pubmed]
  15. Liver 3-phosphoglycerate kinase. Physico-chemical characterization of the bovine-liver enzyme. Kulbe, K.D., Bojanovski, M., Lamprecht, W. Eur. J. Biochem. (1975) [Pubmed]
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