Disease relevance of TRAPPC1

• The average number of membrane particles per mum2 plasma membrane was 710 on face A and 70 on face B of medulloblastoma and 1280 on face A and 160 on face B of cerebellar sarcoma [1].

High impact information on TRAPPC1

• The cell membranes of the terminally differentiated, highly compacted fibroblasts are rich in IMP (1,300/MUM2, P face) [2].
• The optically interactive volume of the microtubule subunit, calculated from our electron microscope determination of spindle microtubule distribution (106/mum2), 13 protofilaments per microtubules, an 8 nm repeat distance and our best value for f, is compatible with known subunit dimensions as determined by other means [3].
• Although transposon insertions are known to suppress recombination and alter the ratio of crossovers to apparent gene conversions, the Mutator 1 transposon insertion in the a1-mum2 allele does not alter the sites at which recombination events resolve [4].
• Gene MUM-2 is homologous to an essential yeast gene, bet5, that was recently shown to be implicated in the vesicular transport of proteins from the endoplasmic reticulum to the Golgi [5].
• Both iso-complexes, Bet3-Tpc6A and Bet3-Tpc6B, are able to recruit Mum2, a further TRAPP subunit, and we identify the alpha1-alpha2 loop regions as a binding site for Mum2 [6].

Biological context of TRAPPC1

• Recombinant A1' alleles isolated from a1-mum2/a1::rdt heterozygotes arose via either crossovers (32 CO events) or noncrossovers (8 NCO events) [7].
• The P-controlled a1 expression in a1-m2 is Spm dependent, and the mutant phenotype of a1-mum2 is suppressed in the pericarp in the absence of the autonomous MuDR element [8].

Anatomical context of TRAPPC1

• The average mitochondrial fraction of the fiber volume is close to 4 percent and the mean size of a mitochondrion is about 0.1 mum2 [9].
• Although both membranes appear to possess about 1,700 intramembranous particles per mum2, those of the luminal membrane tend to be significantly larger in size [10].
• The heterogeneous tissue explant MUM-2 led to the derivation of two clonal cell lines: MUM-2B and MUM-2C [11].
• The number of nuclear pores/mum2 nuclear membrane was not correlated with biological malignancy [12].

Associations of TRAPPC1 with chemical compounds

• Here, we investigated the effect of Mutator and Spm insertions on the expression of the flavonoid biosynthetic gene a1, independently regulated by the transcription factors C1 and P. The a1-mum2 and a1-m2 alleles carry Mu1 and Spm insertions, respectively, in a cis-element (ARE) of unknown function located between the P- and C1-binding sites [8].

Analytical, diagnostic and therapeutic context of TRAPPC1

• The mean cross-sectional area of the muscle fibres in the emphysematous group was 1069-5 mum2 and this was significantly greater than the mean of the control group which was 851-0 mum2 [13].
• An acoustic standing wave is generated in etched glass channels (600 x 61 mum2) by miniature ultrasonic transducers (550 x 550 x 200 mum3) [14].
• The diffusion coefficient was found to be 76.9 mum2 x s(-1) by analytical gel filtration [15].

References