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Gene Review

PRUNE  -  prune exopolyphosphatase

Homo sapiens

Synonyms: DRES-17, DRES17, Drosophila-related expressed sequence 17, HTCD37, HTcD37, ...
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Disease relevance of PRUNE


High impact information on PRUNE

  • BACKGROUND: Prune belly syndrome is a rare and complicated condition affecting the genitourinary organs and abdominal wall [4].
  • Despite adequate bladder catheterization, a neonate with Prune Belly Syndrome developed urinary ascites secondary to forniceal rupture [2].
  • Even though most children with Prune Belly Syndrome respond to lower urinary tract drainage, a cutaneous pyelostomy may be necessary when the ureters are tortuous and do not drain adequately following bladder decompression [2].
  • Special imaging casebook. Prune-belly syndrome with urachal diverticular calcification, posterior urethral valves, and patent utricle [5].

Analytical, diagnostic and therapeutic context of PRUNE

  • Surgical correction and rehabilitation for children with "Prune-belly" syndrome [6].
  • The authors discuss a case of "Prune-belly syndrome" which could be diagnosed prenatally thanks to echography; they stress the importance of echographic controls since the first gestational weeks to better recognize pathological findings, and describe their attempts to drain the megavesica [7].


  1. Ultrasound diagnosis and perinatal management of fetal genito-urinary abnormalities. Kurjak, A., Latin, V., Mandruzzato, G., D'Addario, V., Rajhvajn, B. Journal of perinatal medicine. (1984) [Pubmed]
  2. Urinary ascites secondary to forniceal rupture in a child with the Prune Belly Syndrome. Caruso, D.J., Ankem, M.K., Riordan, J., Barone, J.G. The Canadian journal of urology. (2003) [Pubmed]
  3. Urodynamic studies in prune belly syndrome. A case report. Palmtag, H., Dreikorn, K., Röhl, L. Scandinavian journal of urology and nephrology. (1979) [Pubmed]
  4. Etiology of prune belly syndrome: evidence of megalocystic origin in an early fetus. Terada, S., Suzuki, N., Uchide, K., Ueno, H., Akasofu, K. Obstetrics and gynecology. (1994) [Pubmed]
  5. Special imaging casebook. Prune-belly syndrome with urachal diverticular calcification, posterior urethral valves, and patent utricle. Herman, T.E., Siegel, M.J. Journal of perinatology : official journal of the California Perinatal Association. (1999) [Pubmed]
  6. Surgical correction and rehabilitation for children with "Prune-belly" syndrome. Randolph, J., Cavett, C., Eng, G. Ann. Surg. (1981) [Pubmed]
  7. A case of prune-belly syndrome: prenatal diagnostic problems. Gigli, C., Azzarita, A., D'Ottavio, G., Rustico, M.A., Mandruzzato, G.P. Clinical and experimental obstetrics & gynecology. (1981) [Pubmed]
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