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Gene Review

RASGRF2  -  Ras protein-specific guanine nucleotide...

Homo sapiens

Synonyms: GRF2, RAS-GRF2, Ras guanine nucleotide exchange factor 2, Ras-GRF2, Ras-specific guanine nucleotide-releasing factor 2
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Disease relevance of RASGRF2


High impact information on RASGRF2

  • With the aid of H-Ras constructs specifically tethered to the plasma membrane, endoplasmic reticulum, and Golgi complex, we demonstrate that RasGRF1 and RasGRF2 can activate plasma membrane and reticular, but not Golgi-associated, H-Ras [2].
  • Cdc42N17 was also found to inhibit the translocation of Ras-GRF2, a guanine nucleotide exchange factor for Ras and Rac but not for Cdc42 [3].
  • GRF2 lacking the Cdc25 domain is not ubiquitinated, suggesting that a protein that cannot bind Ras cannot be properly targeted for destruction [4].
  • Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2 [4].
  • Point mutations within the Cdc25 domain that eliminate Ras binding also eliminate ubiquitination, demonstrating that binding to Ras is necessary for ubiquitination of GRF2 [4].

Biological context of RASGRF2


Anatomical context of RASGRF2


Associations of RASGRF2 with chemical compounds

  • Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras [7].

Regulatory relationships of RASGRF2


Other interactions of RASGRF2


  1. Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. Chen, H., Suzuki, M., Nakamura, Y., Ohira, M., Ando, S., Iida, T., Nakajima, T., Nakagawara, A., Kimura, H. Oncol. Rep. (2006) [Pubmed]
  2. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Arozarena, I., Matallanas, D., Berciano, M.T., Sanz-Moreno, V., Calvo, F., Muñoz, M.T., Egea, G., Lafarga, M., Crespo, P. Mol. Cell. Biol. (2004) [Pubmed]
  3. Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells. Rabiet, M.J., Tardif, M., Braun, L., Boulay, F. Blood (2002) [Pubmed]
  4. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. de Hoog, C.L., Koehler, J.A., Goldstein, M.D., Taylor, P., Figeys, D., Moran, M.F. Mol. Cell. Biol. (2001) [Pubmed]
  5. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Anborgh, P.H., Qian, X., Papageorge, A.G., Vass, W.C., DeClue, J.E., Lowy, D.R. Mol. Cell. Biol. (1999) [Pubmed]
  6. Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors. Gotoh, T., Tian, X., Feig, L.A. J. Biol. Chem. (2001) [Pubmed]
  7. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Fam, N.P., Fan, W.T., Wang, Z., Zhang, L.J., Chen, H., Moran, M.F. Mol. Cell. Biol. (1997) [Pubmed]
  8. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Fan, W.T., Koch, C.A., de Hoog, C.L., Fam, N.P., Moran, M.F. Curr. Biol. (1998) [Pubmed]
  9. Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2. de Hoog, C.L., Fan, W.T., Goldstein, M.D., Moran, M.F., Koch, C.A. Mol. Cell. Biol. (2000) [Pubmed]
  10. p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. Kesavapany, S., Amin, N., Zheng, Y.L., Nijhara, R., Jaffe, H., Sihag, R., Gutkind, J.S., Takahashi, S., Kulkarni, A., Grant, P., Pant, H.C. J. Neurosci. (2004) [Pubmed]
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