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Gene Review

RBM3  -  RNA binding motif (RNP1, RRM) protein 3

Homo sapiens

Synonyms: IS1-RNPL, RNA-binding motif protein 3, RNA-binding protein 3, RNPL
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Disease relevance of RBM3


High impact information on RBM3

  • NACA was recently defined as a coactivator of c-jun-mediated transcription factors in osteoblasts, and RBM3 as a protein from the heterogeneous nuclear ribonucleoprotein family [2].
  • We report here the cloning of mouse Rbm3 cDNA, which encoded an 18-kd protein with 94% identity in amino acid sequence to that of human RBM3 [3].
  • Host-encoded proteins hnRNP A2 and RBM3 may also interact with these viral factors to influence late gene expression [4].
  • We also found an association of borderline significance (P=0.05) between the expression of RBM3, the large variant of RBM10 and wild-type p53 [5].
  • Protein synthesis inhibitors cycloheximide and puromycin induced RBM3 transcripts, but cadmium chloride, H2O2, ethanol, and osmotic shock had no effect [6].

Biological context of RBM3

  • Hypoxia-induced RBM3 or CIRP transcription was inhibited by the respiratory chain inhibitors NaN(3) and cyanide in a dose-dependent fashion [1].
  • In NC65 cells, the kinetics of RBM3 induction was different from that of CIRP [6].
  • Combined with the different tissue distribution of expression, these results suggest that RBM3 and CIRP play distinct roles in cold responses of human cells [6].

Anatomical context of RBM3

  • RBM3 transcripts were constitutively expressed in all cell lines examined including K562, HepG2, NC65, HeLa, and T24 cells [6].

Other interactions of RBM3

  • Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress [6].


  1. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. Wellmann, S., Bührer, C., Moderegger, E., Zelmer, A., Kirschner, R., Koehne, P., Fujita, J., Seeger, K. J. Cell. Sci. (2004) [Pubmed]
  2. Capture of cytokine-responsive genes (NACA and RBM3) using a gene trap approach. Baghdoyan, S., Dubreuil, P., Eberlé, F., Gomez, S. Blood (2000) [Pubmed]
  3. Decreased expression of mouse Rbm3, a cold-shock protein, in Sertoli cells of cryptorchid testis. Danno, S., Itoh, K., Matsuda, T., Fujita, J. Am. J. Pathol. (2000) [Pubmed]
  4. Protein interactions among the vaccinia virus late transcription factors. Dellis, S., Strickland, K.C., McCrary, W.J., Patel, A., Stocum, E., Wright, C.F. Virology (2004) [Pubmed]
  5. Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer. Martínez-Arribas, F., Agudo, D., Pollán, M., Gómez-Esquer, F., Díaz-Gil, G., Lucas, R., Schneider, J. J. Cell. Biochem. (2006) [Pubmed]
  6. Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress. Danno, S., Nishiyama, H., Higashitsuji, H., Yokoi, H., Xue, J.H., Itoh, K., Matsuda, T., Fujita, J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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