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Gene Review

Tsn  -  translin

Rattus norvegicus

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Disease relevance of Tsn


High impact information on Tsn


Anatomical context of Tsn

  • Sequencing of peptides derived from these proteins led to their identification as Translin and Trax, interacting proteins identified in studies of DNA recombination in lymphocytes [4].
  • Furthermore, immunohistochemical studies with Translin antibodies revealed prominent staining in Purkinje neuron cell bodies that extends into proximal and distal dendrites [2].

Physical interactions of Tsn

  • Whether one or both of these proposed functions of the Translin/Trax complex explains the high basal level of GS1 binding activity present in the brain remains to be determined [4].


  1. Trypsin display on the surface of bacteriophage. Corey, D.R., Shiau, A.K., Yang, Q., Janowski, B.A., Craik, C.S. Gene (1993) [Pubmed]
  2. Somatodendritic localization of Translin, a component of the Translin/Trax RNA binding complex. Finkenstadt, P.M., Kang, W.S., Jeon, M., Taira, E., Tang, W., Baraban, J.M. J. Neurochem. (2000) [Pubmed]
  3. Identification of Translin/Trax complex as a glucose response element binding protein in liver. Wu, R.F., Osatomi, K., Terada, L.S., Uyeda, K. Biochim. Biophys. Acta (2003) [Pubmed]
  4. Identification of translin and trax as components of the GS1 strand-specific DNA binding complex enriched in brain. Taira, E., Finkenstadt, P.M., Baraban, J.M. J. Neurochem. (1998) [Pubmed]
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