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Gene Review

Tsn  -  translin

Mus musculus

Synonyms: 2610034C24Rik, AU040286, C3PO, Component 3 of promoter of RISC, TB-RBP, ...
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Psychiatry related information on Tsn


High impact information on Tsn


Biological context of Tsn


Anatomical context of Tsn


Associations of Tsn with chemical compounds


Physical interactions of Tsn


Co-localisations of Tsn


Regulatory relationships of Tsn


Other interactions of Tsn

  • In addition to a leucine zipper, two basic domains in TB-RBP are essential for RNA binding, but only one of these domains is needed for DNA binding [4].
  • No translational inhibition by recombinant TB-RBP was seen with Gapds mRNA lacking the H element [5].
  • The testis brain RNA-binding protein (TB-RBP) functions as an RNA-binding protein in brain and testis, binding to conserved sequence elements present in specific mRNAs, such as protamine 1 and 2 [17].
  • AKAP4 mRNA forms a complex with TB-RBP and the Ter ATPase in nuclei and remains associated with these proteins as it exits nuclei into the cytoplasm and as it passes through intercellular bridges between spermatids [17].

Analytical, diagnostic and therapeutic context of Tsn


  1. Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. Stein, J.M., Bergman, W., Fang, Y., Davison, L., Brensinger, C., Robinson, M.B., Hecht, N.B., Abel, T. J. Neurosci. (2006) [Pubmed]
  2. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Chennathukuzhi, V., Morales, C.R., El-Alfy, M., Hecht, N.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. The RNA-binding protein, TB-RBP, is the mouse homologue of translin, a recombination protein associated with chromosomal translocations. Wu, X.Q., Gu, W., Meng, X., Hecht, N.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA. Chennathukuzhi, V.M., Kurihara, Y., Bray, J.D., Hecht, N.B. J. Biol. Chem. (2001) [Pubmed]
  5. Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S and suppresses its translation in vitro. Yang, J., Chennathukuzhi, V., Miki, K., O'Brien, D.A., Hecht, N.B. Biol. Reprod. (2003) [Pubmed]
  6. Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype. Chennathukuzhi, V.M., Kurihara, Y., Bray, J.D., Yang, J., Hecht, N.B. Nucleic Acids Res. (2001) [Pubmed]
  7. The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells. Cho, Y.S., Chennathukuzhi, V.M., Handel, M.A., Eppig, J., Hecht, N.B. J. Biol. Chem. (2004) [Pubmed]
  8. Testis/brain RNA-binding protein attaches translationally repressed and transported mRNAs to microtubules. Han, J.R., Yiu, G.K., Hecht, N.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Chennathukuzhi, V., Stein, J.M., Abel, T., Donlon, S., Yang, S., Miller, J.P., Allman, D.M., Simmons, R.A., Hecht, N.B. Mol. Cell. Biol. (2003) [Pubmed]
  10. Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation. Yang, S., Cho, Y.S., Chennathukuzhi, V.M., Underkoffler, L.A., Loomes, K., Hecht, N.B. J. Biol. Chem. (2004) [Pubmed]
  11. BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein. Muramatsu, T., Ohmae, A., Anzai, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  12. Circadian rhythm of thymosin-alpha 1 in normal and thymectomized mice. McGillis, J.P., Hall, N.R., Goldstein, A.L. J. Immunol. (1983) [Pubmed]
  13. Evidence for the interaction between Translin and GADD34 in mammalian cells. Hasegawa, T., Isobe, K. Biochim. Biophys. Acta (1999) [Pubmed]
  14. KIF2Abeta: A kinesin family member enriched in mouse male germ cells, interacts with translin associated factor-X (TRAX). Bray, J.D., Chennathukuzhi, V.M., Hecht, N.B. Mol. Reprod. Dev. (2004) [Pubmed]
  15. Elevated levels of the polyadenylation factor CstF 64 enhance formation of the 1kB Testis brain RNA-binding protein (TB-RBP) mRNA in male germ cells. Chennathukuzhi, V.M., Lefrancois, S., Morales, C.R., Syed, V., Hecht, N.B. Mol. Reprod. Dev. (2001) [Pubmed]
  16. Mouse testis brain ribonucleic acid-binding protein/translin colocalizes with microtubules and is immunoprecipitated with messenger ribonucleic acids encoding myelin basic protein, alpha calmodulin kinase II, and protamines 1 and 2. Wu, X.Q., Hecht, N.B. Biol. Reprod. (2000) [Pubmed]
  17. A TB-RBP and Ter ATPase complex accompanies specific mRNAs from nuclei through the nuclear pores and into intercellular bridges in mouse male germ cells. Morales, C.R., Lefrancois, S., Chennathukuzhi, V., El-Alfy, M., Wu, X., Yang, J., Gerton, G.L., Hecht, N.B. Dev. Biol. (2002) [Pubmed]
  18. Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis. Cho, Y.S., Iguchi, N., Yang, J., Handel, M.A., Hecht, N.B. Biol. Reprod. (2005) [Pubmed]
  19. Translin coactivates steroidogenic factor-1-stimulated transcription. Mellon, S.H., Bair, S.R., Depoix, C., Vigne, J.L., Hecht, N.B., Brake, P.B. Mol. Endocrinol. (2007) [Pubmed]
  20. The RNA- and DNA-binding protein TB-RBP is spatially and developmentally regulated during spermatogenesis. Gu, W., Wu, X.Q., Meng, X.H., Morales, C., el-Alfy, M., Hecht, N.B. Mol. Reprod. Dev. (1998) [Pubmed]
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