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Gene Review

TSN  -  translin

Homo sapiens

Synonyms: BCLF-1, C3PO, Component 3 of promoter of RISC, RCHF1, REHF-1, ...
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Disease relevance of TSN


Psychiatry related information on TSN

  • The sample consisted of 18 men, aged 48-80, participants in the Normative Aging Study. While none of the correlations reached significance in the baseline condition, life events and depressive symptoms were significantly correlated with TSN-alpha 1 in the postchallenge condition (r's = .57, and .62, respectively) [5].
  • Thus, these preliminary results suggest that psychosocial factors may be related to abnormal TSN-alpha 1 responses to a challenge [5].

High impact information on TSN


Chemical compound and disease context of TSN


Biological context of TSN

  • We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence of consensus recognition motifs of Translin, a protein that associates with chromosomal translocations of lymphoid neoplasms [1].
  • Based on our data, we propose that translin might be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance [10].
  • Translin is a recently identified nucleic acid binding protein that appears to be involved in the recognition of conserved sequences found at many chromosomal breakpoints [11].
  • Analysis of the human and mouse Translin genes revealed that they have identical genomic structures consisting of six exons, five introns, and a GC-rich upstream region [12].
  • From comparisons of the amino acid sequences in humans and other vertebrates, we conclude that Translin has been highly conserved during evolution, especially at the leucine zipper motif and the basic region, which is thought to be the DNA binding domain [12].

Anatomical context of TSN

  • All of 13 oligonucleotides corresponding to the putative binding sequences in these cases bind to Hela cell extract and also recombinant Translin protein, although the binding affinity of each motif showed considerable differences [1].
  • Here we report the cloning of the Xenopus homologue of the TB-RBP/Translin protein (X-translin) as well as its expression, its localisation, and its biochemical association with the protein named Translin associated factor X (Trax) in Xenopus oocytes [13].
  • One thymic fraction, thymosin-alpha 1 (TSN-alpha 1) may be of particular interest given its hypothesized role in the differentiation of immature T cells into functional, mature T cells [5].
  • Antimicrobial resistance patterns among the principal bacterial pathogens from infections of the respiratory tract, blood, skin and soft tissue, and urinary tract of pediatric patients from the USA, Canada, Germany, France, and Italy were studied using the The Surveillance Network (TSN) database [14].
  • Reaction of this enzyme in the neuropil varies from strong (NNH, NPH, VSP, VM, VS, VL, OLS, NI, NRM), over moderate (reticular nuclei, NS, TSN), mild (NA, NRL) to absent (AP) [15].

Associations of TSN with chemical compounds

  • Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer [16].
  • We examined the relationships among stress, psychological symptoms, and TSN-alpha 1 levels in two conditions; before and after a glucose challenge test [5].
  • We reviewed the activity of ceftriaxone and relevant comparative agents against five Gram-positive and 11 Gram-negative species for a 5-year period, 1996-2000, using data from The Surveillance Network (TSN) Database-USA [17].
  • The nifedipine-sensitive L-type currents were significantly increased after exposure to TSN while the nifedipine-resistant or omega-conotoxin MVIIC-sensitive currents were not affected [18].

Physical interactions of TSN

  • These results suggest that one role for C1D may be to regulate TRAX/Translin complex formation [19].

Other interactions of TSN


Analytical, diagnostic and therapeutic context of TSN


  1. Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6). Hosaka, T., Kanoe, H., Nakayama, T., Murakami, H., Yamamoto, H., Nakamata, T., Tsuboyama, T., Oka, M., Kasai, M., Sasaki, M.S., Nakamura, T., Toguchida, J. Oncogene (2000) [Pubmed]
  2. Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus. Li, K., Wang, L., Cheng, J., Lu, Y.Y., Zhang, L.X., Mu, J.S., Hong, Y., Liu, Y., Duan, H.J., Wang, G., Li, L., Chen, J.M. World J. Gastroenterol. (2003) [Pubmed]
  3. Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX. Laufman, O., Ben Yosef, R., Adir, N., Manor, H. Nucleic Acids Res. (2005) [Pubmed]
  4. Susceptibility to fluoroquinolones among commonly isolated Gram-negative bacilli in 2000: TRUST and TSN data for the United States. Tracking Resistance in the United States Today. The Surveillance Network. Karlowsky, J.A., Kelly, L.J., Thornsberry, C., Jones, M.E., Evangelista, A.T., Critchley, I.A., Sahm, D.F. Int. J. Antimicrob. Agents (2002) [Pubmed]
  5. Thymic peptides, stress, and depressive symptoms in older men: a comparison of different statistical techniques for small samples. Aldwin, C.M., Spiro, A., Clark, G., Hall, N. Brain Behav. Immun. (1991) [Pubmed]
  6. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Aoki, K., Suzuki, K., Sugano, T., Tasaka, T., Nakahara, K., Kuge, O., Omori, A., Kasai, M. Nat. Genet. (1995) [Pubmed]
  7. Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination. Badge, R.M., Yardley, J., Jeffreys, A.J., Armour, J.A. Hum. Mol. Genet. (2000) [Pubmed]
  8. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. Kasai, M., Matsuzaki, T., Katayanagi, K., Omori, A., Maziarz, R.T., Strominger, J.L., Aoki, K., Suzuki, K. J. Biol. Chem. (1997) [Pubmed]
  9. Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States. Karlowsky, J.A., Kelly, L.J., Thornsberry, C., Jones, M.E., Sahm, D.F. Antimicrob. Agents Chemother. (2002) [Pubmed]
  10. The human protein translin specifically binds single-stranded microsatellite repeats, d(GT)n, and G-strand telomeric repeats, d(TTAGGG)n: a study of the binding parameters. Jacob, E., Pucshansky, L., Zeruya, E., Baran, N., Manor, H. J. Mol. Biol. (2004) [Pubmed]
  11. Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide. Lee, S.P., Fuior, E., Lewis, M.S., Han, M.K. Biochemistry (2001) [Pubmed]
  12. Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. Aoki, K., Inazawa, J., Takahashi, T., Nakahara, K., Kasai, M. Genomics (1997) [Pubmed]
  13. Part of Xenopus translin is localized in the centrosomes during mitosis. Castro, A., Peter, M., Magnaghi-Jaulin, L., Vigneron, S., Loyaux, D., Lorca, T., Labbé, J.C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  14. Rates of antimicrobial resistance among common bacterial pathogens causing respiratory, blood, urine, and skin and soft tissue infections in pediatric patients. Jones, M.E., Karlowsky, J.A., Draghi, D.C., Thornsberry, C., Sahm, D.F., Bradley, J.S. Eur. J. Clin. Microbiol. Infect. Dis. (2004) [Pubmed]
  15. Histological and histoenzymological studies on the medulla oblongata and pons of hedgehog (Paraechinus micropus). Mohanakumar, K.P., Sood, P.P. Acta morphologica Neerlando-Scandinavica. (1980) [Pubmed]
  16. Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer. Han, M.K., Lin, P., Paek, D., Harvey, J.J., Fuior, E., Knutson, J.R. Biochemistry (2002) [Pubmed]
  17. Ceftriaxone activity against Gram-positive and Gram-negative pathogens isolated in US clinical microbiology laboratories from 1996 to 2000: results from The Surveillance Network (TSN) Database-USA. Karlowsky, J.A., Jones, M.E., Mayfield, D.C., Thornsberry, C., Sahm, D.F. Int. J. Antimicrob. Agents (2002) [Pubmed]
  18. The long-term effect of toosendanin on current through nifedipine-sensitive Ca2+ channels in NG108-15 cells. Li, M.F., Shi, Y.L. Toxicon (2005) [Pubmed]
  19. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). Erdemir, T., Bilican, B., Oncel, D., Goding, C.R., Yavuzer, U. J. Cell. Sci. (2002) [Pubmed]
  20. Co-expressed recombinant human Translin-Trax complex binds DNA. Gupta, G.D., Makde, R.D., Kamdar, R.P., D'Souza, J.S., Kulkarni, M.G., Kumar, V., Rao, B.J. FEBS Lett. (2005) [Pubmed]
  21. Conformational changes induced in the human protein translin and in the single-stranded oligodeoxynucleotides d(GT)(12) and d(TTAGGG)(5) upon binding of these oligodeoxynucleotides by translin. Kaluzhny, D., Laufman, O., Timofeev, E., Borisova, O., Manor, H., Shchyolkina, A. J. Biomol. Struct. Dyn. (2005) [Pubmed]
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