Disease relevance of BRCA3

• Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium [1].
• Implication of the BRCA2 and putative "BRCA3" genes in Dukes' stage C, replication error-negative colon cancer [2].
• We applied comparative genomic hybridization (CGH) to identify the most frequent genomic imbalances in 18 BRCAX hereditary breast cancers and compared them to chromosomal aberrations detected in a group of 27 sporadic breast cancers [3].
• Nine patients, (breast cancer 3, malignant lymphoma 4 and AML 2), who underwent ABMT following preparative regimens with comparable doses of Mito, served as controls [4].

High impact information on BRCA3

• This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases [5].
• The findings of this report indicate similarities between BRCAX and BRCA2 tumours, possibly suggesting a common pathway of disease [3].
• Comparison of genomic abnormalities between BRCAX and sporadic breast cancers studied by comparative genomic hybridization [3].
• CONCLUSIONS: The intragenic markers D13S1308 (BRCA3) and D13S171 (BRCA2) on chromosome 13 demonstrated a high frequency of allelic imbalance in primary colon carcinoma [2].
• After taking the IGFBP3 genotype into account, IGFBP-3 levels were still significantly higher in women from BRCAX families during cycle days 18-23 (P=0.004) [6].

Biological context of BRCA3

• The best-fitting single gene model for BRCA3 was a recessive model with a disease allele frequency 24% and penetrance 42% by age 70 [7].
• Our findings considerably strengthen the evidence for a third breast cancer susceptibility locus (BRCA3) mapping to the short arm of human chromosome 8 [8].
• 13q has been done in 55 primary HNSCC samples of Indian patients using 11 highly polymorphic microsatellite markers of which three were intragenic to BRCA2 gene, one intragenic to RB1 gene and another from BRCAX locus [9].
• Previous studies failed to identify common deleted regions in chr.13q, though several candidate tumour suppressor genes (TSGs) loci, e.g. BRCA2, RB1 and BRCAX have been localized in this chromosome, as well as no prognostic significance of the deletion has been reported [9].

Associations of BRCA3 with chemical compounds

• On questioning her past medical history included a diagnosis of breast cancer 3 years ago treated by radical mastectomy and tamoxifen 20 mg daily [10].

Other interactions of BRCA3

• BRCA1, BRCA2, BRCA3 ... a myriad of breast cancer genes [11].
• We estimated the simultaneous effects of BRCA1, BRCA2, a third hypothetical gene 'BRCA3', and a polygenic effect using segregation analysis [12].

References