The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

KCNK15  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: Acid-sensitive potassium channel protein TASK-5, K2p15.1, KCNK11, KCNK14, KIAA0237, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on KCNK15

 

Biological context of KCNK15

 

Anatomical context of KCNK15

  • Thus, TASK-5 is a new member of the tandem-pore K(+) channel family but does not produce a functional plasma membrane K(+) current by itself [4].
  • Neither form of TASK-5 showed channel activity when transfected in COS-7 cells [4].
  • TASK-5 mRNA is expressed in pancreas, liver, kidney, lung, ovary, testis and heart [5].
  • Nonetheless, TASK-5 may require some other, unidentified partner subunit to form functional channels in the plasma membrane or it may form a channel in an intracellular organelle [5].
  • Removal of a putative endoplasmic reticulum retention sequence did not alter this finding and the distribution of channel proteins in HEK293 cells was similar for both TASK-1 and TASK-5 [5].
 

Analytical, diagnostic and therapeutic context of KCNK15

References

  1. Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. Karschin, C., Wischmeyer, E., Preisig-Müller, R., Rajan, S., Derst, C., Grzeschik, K.H., Daut, J., Karschin, A. Mol. Cell. Neurosci. (2001) [Pubmed]
  2. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. Rajan, S., Preisig-Müller, R., Wischmeyer, E., Nehring, R., Hanley, P.J., Renigunta, V., Musset, B., Schlichthörl, G., Derst, C., Karschin, A., Daut, J. J. Physiol. (Lond.) (2002) [Pubmed]
  3. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. Vega-Saenz de Miera, E., Lau, D.H., Zhadina, M., Pountney, D., Coetzee, W.A., Rudy, B. J. Neurophysiol. (2001) [Pubmed]
  4. TASK-5, a new member of the tandem-pore K(+) channel family. Kim, D., Gnatenco, C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. TASK-5, a novel member of the tandem pore K+ channel family. Ashmole, I., Goodwin, P.A., Stanfield, P.R. Pflugers Arch. (2001) [Pubmed]
  6. Tryptophan depletion decreases the recognition of fear in female volunteers. Harmer, C.J., Rogers, R.D., Tunbridge, E., Cowen, P.J., Goodwin, G.M. Psychopharmacology (Berl.) (2003) [Pubmed]
 
WikiGenes - Universities