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Gene Review

KCNK15  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: Acid-sensitive potassium channel protein TASK-5, K2p15.1, KCNK11, KCNK14, KIAA0237, ...
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High impact information on KCNK15


Biological context of KCNK15


Anatomical context of KCNK15

  • Thus, TASK-5 is a new member of the tandem-pore K(+) channel family but does not produce a functional plasma membrane K(+) current by itself [4].
  • Neither form of TASK-5 showed channel activity when transfected in COS-7 cells [4].
  • TASK-5 mRNA is expressed in pancreas, liver, kidney, lung, ovary, testis and heart [5].
  • Nonetheless, TASK-5 may require some other, unidentified partner subunit to form functional channels in the plasma membrane or it may form a channel in an intracellular organelle [5].
  • Removal of a putative endoplasmic reticulum retention sequence did not alter this finding and the distribution of channel proteins in HEK293 cells was similar for both TASK-1 and TASK-5 [5].

Analytical, diagnostic and therapeutic context of KCNK15


  1. Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. Karschin, C., Wischmeyer, E., Preisig-Müller, R., Rajan, S., Derst, C., Grzeschik, K.H., Daut, J., Karschin, A. Mol. Cell. Neurosci. (2001) [Pubmed]
  2. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. Rajan, S., Preisig-Müller, R., Wischmeyer, E., Nehring, R., Hanley, P.J., Renigunta, V., Musset, B., Schlichthörl, G., Derst, C., Karschin, A., Daut, J. J. Physiol. (Lond.) (2002) [Pubmed]
  3. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. Vega-Saenz de Miera, E., Lau, D.H., Zhadina, M., Pountney, D., Coetzee, W.A., Rudy, B. J. Neurophysiol. (2001) [Pubmed]
  4. TASK-5, a new member of the tandem-pore K(+) channel family. Kim, D., Gnatenco, C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. TASK-5, a novel member of the tandem pore K+ channel family. Ashmole, I., Goodwin, P.A., Stanfield, P.R. Pflugers Arch. (2001) [Pubmed]
  6. Tryptophan depletion decreases the recognition of fear in female volunteers. Harmer, C.J., Rogers, R.D., Tunbridge, E., Cowen, P.J., Goodwin, G.M. Psychopharmacology (Berl.) (2003) [Pubmed]
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