Gene Review:
IL6R - interleukin 6 receptor
Homo sapiens
Synonyms:
CD126, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-1, ...
Kawatani,
Rossi,
Hess,
Wichter,
Kawasaki,
Hamid,
Flesch,
Kube,
Jensen,
Pedersen,
Sandaradura De Silva,
Flucke,
Eschert,
Deng,
Borgna,
Reinhold,
Erren,
Smola,
Bogardus,
Hansen,
Böhm,
Pfister,
Baldus,
Glümer,
Synowitz,
Ansorge,
Plenz,
Tajima,
Nanba,
Colligan,
Ishiga,
Ohmura,
Schneemilch,
Jørgensen,
Bongioanni,
Kunz,
Omura,
Hadaschik,
Scheld,
Borch-Johnsen,
Boccardi,
Gruber,
Urhammer,
Wolford,
Bank,
- Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. Hamid, Y.H., Urhammer, S.A., Jensen, D.P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, T., Pedersen, O. Diabetes (2004)
- The interleukin-6/interleukin-6-receptor system is activated in donor hearts. Plenz, G., Eschert, H., Erren, M., Wichter, T., Böhm, M., Flesch, M., Scheld, H.H., Deng, M.C. J. Am. Coll. Cardiol. (2002)
- The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand. Zohlnhöfer, D., Graeve, L., Rose-John, S., Schooltink, H., Dittrich, E., Heinrich, P.C. FEBS Lett. (1992)
- IL6 and IL6 receptor expression in Burkitt's lymphoma and lymphoblastoid cell lines: promotion of IL6 receptor expression by EBV. Klein, S.C., Jücker, M., Abts, H., Tesch, H. Hematological oncology. (1995)
- Identification of novel SNPs in the interleukin 6 receptor gene (IL6R). Kim, L.H., Lee, H.S., Kim, Y.J., Jung, J.H., Kim, J.Y., Park, B.L., Shin, H.D. Hum. Mutat. (2003)
- Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. Briso, E.M., Dienz, O., Rincon, M. J. Immunol. (2008)
- Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study. Bagli, M., Papassotiropoulos, A., Hampel, H., Becker, K., Jessen, F., Bürger, K., Ptok, U., Rao, M.L., Möller, H.J., Maier, W., Heun, R. European archives of psychiatry and clinical neuroscience. (2003)
- Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Maes, M., Lin, A.H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., Bosmans, E. Biol. Psychiatry (1999)
- T-lymphocyte interleukin 6 receptor binding in patients with dementia of Alzheimer type. Bongioanni, P., Boccardi, B., Borgna, M., Rossi, B. Arch. Neurol. (1998)
- Linkage of pycnodysostosis to chromosome 1q21 by homozygosity mapping. Gelb, B.D., Edelson, J.G., Desnick, R.J. Nat. Genet. (1995)
- Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Gearing, D.P., Cosman, D. Cell (1991)
- Molecular cloning and expression of an IL-6 signal transducer, gp130. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., Kishimoto, T. Cell (1990)
- Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., Strand, D., Czaja, J., Schlaak, J.F., Lehr, H.A., Autschbach, F., Schürmann, G., Nishimoto, N., Yoshizaki, K., Ito, H., Kishimoto, T., Galle, P.R., Rose-John, S., Neurath, M.F. Nat. Med. (2000)
- Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells. Snyers, L., De Wit, L., Content, J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway. Taniguchi, T., Matsuzaki, N., Jo, T., Saji, F., Taga, T., Hirano, T., Kishimoto, T., Tanizawa, O. J. Clin. Endocrinol. Metab. (1992)
- Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) Is Modulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6. Hu, F., Nicholas, J. J. Virol. (2006)
- Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation. Oleksy, A., Banbula, A., Bugno, M., Travis, J., Potempa, J. Microb. Pathog. (2002)
- Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. Strassmann, G., Fong, M., Freter, C.E., Windsor, S., D'Alessandro, F., Nordan, R.P. J. Clin. Invest. (1993)
- Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Wolford, J.K., Colligan, P.B., Gruber, J.D., Bogardus, C. Mol. Genet. Metab. (2003)
- The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21. Kluck, P.M., Wiegant, J., Jansen, R.P., Bolk, M.W., Raap, A.K., Willemze, R., Landegent, J.E. Hum. Genet. (1993)
- Serum soluble IL-6 receptor levels during the mobilization of stem cells to peripheral blood. Omura, H., Kawatani, T., Tajima, F., Ishiga, K., Ohmura, H., Kawasaki, H., Nanba, E. Leuk. Lymphoma (2002)
- Effects of IL6 on B cells in mucosal immune response and inflammation. Fujihashi, K., Kono, Y., Kiyono, H. Res. Immunol. (1992)
- IL-6/BSF-2 selectively stimulates the GO----S progression of CD8+ lymphocytes. Bulgarini, D., Scalzo, S., Boccoli, G., Petrini, M., Quaranta, M.T., Camagna, A., Isacchi, G., Testa, U., Peschle, C. J. Biol. Regul. Homeost. Agents (1991)
- Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction. Ogata, A., Nishimoto, N., Shima, Y., Yoshizaki, K., Kishimoto, T. Blood (1994)
- Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. Puthier, D., Bataille, R., Barillé, S., Mellerin, M.P., Harousseau, J.L., Ponzio, A., Robillard, N., Wijdenes, J., Amiot, M. Blood (1996)
- Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. Vermes, C., Jacobs, J.J., Zhang, J., Firneisz, G., Roebuck, K.A., Glant, T.T. J. Biol. Chem. (2002)
- Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). Matthews, V., Schuster, B., Schütze, S., Bussmeyer, I., Ludwig, A., Hundhausen, C., Sadowski, T., Saftig, P., Hartmann, D., Kallen, K.J., Rose-John, S. J. Biol. Chem. (2003)
- Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction. Kalai, M., Montero-Julian, F.A., Grötzinger, J., Fontaine, V., Vandenbussche, P., Deschuyteneer, R., Wollmer, A., Brailly, H., Content, J. Blood (1997)
- Soluble interleukin-6 receptor strongly increases the production of acute-phase protein by hepatoma cells but exerts minimal changes on human primary hepatocytes. Gabay, C., Silacci, P., Genin, B., Mentha, G., Le Coultre, C., Guerne, P.A. Eur. J. Immunol. (1995)
- Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor. Fourcin, M., Chevalier, S., Lebrun, J.J., Kelly, P., Pouplard, A., Wijdenes, J., Gascan, H. Eur. J. Immunol. (1994)
- Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase. Park, J., Gores, G.J., Patel, T. Hepatology (1999)
- Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation. Bank, U., Reinhold, D., Schneemilch, C., Kunz, D., Synowitz, H.J., Ansorge, S. J. Interferon Cytokine Res. (1999)
- Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production. Hess, S., Smola, H., Sandaradura De Silva, U., Hadaschik, D., Kube, D., Baldus, S.E., Flucke, U., Pfister, H. J. Immunol. (2000)
- A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Molden, J., Chang, Y., You, Y., Moore, P.S., Goldsmith, M.A. J. Biol. Chem. (1997)
- Soluble interleukin-6 receptor enhanced by oncostatin M induces major changes in gene expression profile of human hepatoma cells. Holub, M.C., Hegyesi, H., Igaz, P., Polgár, A., Toth, S., Falus, A. Immunol. Lett. (2002)
- Expression of the interleukin 6 receptor in primary renal cell carcinoma. Costes, V., Liautard, J., Picot, M.C., Robert, M., Lequeux, N., Brochier, J., Baldet, P., Rossi, J.F. J. Clin. Pathol. (1997)
- Interleukin-6 receptor antagonists inhibit interleukin-11 biological activity. Sun, R.X., Gennaro, C., Rocco, S., Gu, Z.J., Klein, B. Eur. Cytokine Netw. (1997)
- IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., Kishimoto, T. Science (1993)
- Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains. Schwabe, M., Brini, A.T., Bosco, M.C., Rubboli, F., Egawa, M., Zhao, J., Princler, G.L., Kung, H.F. J. Clin. Invest. (1994)
- Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells. Gruss, H.J., Brach, M.A., Drexler, H.G., Bonifer, R., Mertelsmann, R.H., Herrmann, F. Cancer Res. (1992)
- Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma. Alexandrakis, M.G., Passam, F.H., Boula, A., Christophoridou, A., Aloizos, G., Roussou, P., Kyriakou, D.S. Ann. Hematol. (2003)
- Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Meyer zum Büschenfelde, K.H., Galle, P.R., Rose-John, S. Gastroenterology (2000)
- Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice. Wüstefeld, T., Rakemann, T., Kubicka, S., Manns, M.P., Trautwein, C. Hepatology (2000)