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Gene Review

RREB1  -  ras responsive element binding protein 1

Homo sapiens

Synonyms: FINB, Finger protein in nuclear bodies, HNT, LZ321, RREB-1, ...
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Disease relevance of RREB1

  • RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas [1].

High impact information on RREB1

  • Here we show that Finb/RREB-1 can associate with BETA2 to enhance its transcription-activating function [2].
  • We identified by expression cloning the zinc finger protein RREB-1, also known to exist as a longer form, Finb, as the protein binding to one of the mutationally sensitive elements [2].
  • Finb/RREB-1 lacks an intrinsic activation domain and by itself did not activate secretin gene transcription [2].
  • By affinity screening, we have cloned a cDNA coding for a zinc finger transcription factor (RREB-1) that binds to the distal RRE [1].
  • These data suggest that RREB-1 may play a role in Ras and Raf signal transduction in medullary thyroid cancer and other cells [1].

Biological context of RREB1


Anatomical context of RREB1


Associations of RREB1 with chemical compounds

  • Finb efficiently activates transcription from the promoters of the metallothionein and thymidine kinase genes [7].

Physical interactions of RREB1


Other interactions of RREB1

  • The Finb protein consists of 1656 amino acids, containing 15 C2H2-type zinc fingers and three proline-rich regions [7].
  • Progressive deletion analysis of LGA promoter-luciferase constructs indicated that the core promoter is located between nt -141 and +410, with several potential regulatory elements: CAAT, GC, TATA-like, Ras-responsive element binding protein and specificity protein 1 (Sp1) sites [9].


  1. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Thiagalingam, A., De Bustros, A., Borges, M., Jasti, R., Compton, D., Diamond, L., Mabry, M., Ball, D.W., Baylin, S.B., Nelkin, B.D. Mol. Cell. Biol. (1996) [Pubmed]
  2. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Ray, S.K., Nishitani, J., Petry, M.W., Fessing, M.Y., Leiter, A.B. Mol. Cell. Biol. (2003) [Pubmed]
  3. A human Raf-responsive zinc-finger protein that binds to divergent sequences. Zhang, L., Zhao, J., Edenberg, H.J. Nucleic Acids Res. (1999) [Pubmed]
  4. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. Thiagalingam, A., Lengauer, C., Baylin, S.B., Nelkin, B.D. Genomics (1997) [Pubmed]
  5. Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA. Tamori, A., Yamanishi, Y., Kawashima, S., Kanehisa, M., Enomoto, M., Tanaka, H., Kubo, S., Shiomi, S., Nishiguchi, S. Clin. Cancer Res. (2005) [Pubmed]
  6. Cross talk of two Krupple transcription factors regulates expression of the ovine FSH receptor gene. Xing, W., Sairam, M.R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  7. A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies. Fujimoto-Nishiyama, A., Ishii, S., Matsuda, S., Inoue, J., Yamamoto, T. Gene (1997) [Pubmed]
  8. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mukhopadhyay, N.K., Cinar, B., Mukhopadhyay, L., Lutchman, M., Ferdinand, A.S., Kim, J., Chung, L.W., Adam, R.M., Ray, S.K., Leiter, A.B., Richie, J.P., Liu, B.C., Freeman, M.R. Mol. Endocrinol. (2007) [Pubmed]
  9. Genomic organization and transcriptional analysis of the human l-glutaminase gene. Pérez-Gómez, C., Matés, J.M., Gómez-Fabre, P.M., del Castillo-Olivares, A., Alonso, F.J., Márquez, J. Biochem. J. (2003) [Pubmed]
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